Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism.
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Targeting the insulin growth factor receptor 1Cross talk of tyrosine kinases with the DNA damage signaling pathwaysCompounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cellsThe insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies.Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy.Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Small-molecule ATP-competitive dual IGF-1R and insulin receptor inhibitors: structural insights, chemical diversity and molecular evolution.Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers.Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescenceRole of IGF-1 receptor in radiation response.Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.Tamoxifen prevents apoptosis and follicle loss from cyclophosphamide in cultured rat ovaries.Challenges and Potential for Ovarian Preservation with SERMs.MVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapy.Nutrient restriction and radiation therapy for cancer treatment: when less is moreThe status of targeted agents in the setting of neoadjuvant radiation therapy in locally advanced rectal cancers.Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cellsCrosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.Non-classical p38 map kinase functions: cell cycle checkpoints and survival.IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insightsEphrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancerSmall molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer.Beyond ATM: the protein kinase landscape of the DNA damage response.Molecular Targeting of Growth Factor Receptor Signaling in Radiation Oncology.IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit.7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells.Phosphoprotein analysis reveals MEK inhibition as a way to target non-small cell lung cancer tumor initiating cells.miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence.Helianthin induces antiproliferative effect on human glioblastoma cells in vitro.IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer.Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer.Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549.IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer.IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance.The Influence of EGFR Inactivation on the Radiation Response in High Grade Glioma.
P2860
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P2860
Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Ionizing radiation activates I ...... 38 kinase-dependent mechanism.
@en
type
label
Ionizing radiation activates I ...... 38 kinase-dependent mechanism.
@en
prefLabel
Ionizing radiation activates I ...... 38 kinase-dependent mechanism.
@en
P2093
P2860
P356
P1433
P1476
Ionizing radiation activates I ...... 38 kinase-dependent mechanism.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210037
P407
P577
2006-10-09T00:00:00Z
P5875
P6179
1022191857