Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. - Wikidata - wikimedia - TriplyDB

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

http://www.wikidata.org/entity/Q40221922

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P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Molecular and functional properties of P2X receptors--recent progress and persisting challenges The NLRP3 inflammasome and stroke P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue Cloning and pharmacological characterization of the dog P2X7 receptor.Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus.Differential role of pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes.Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers Proteoglycans act as cellular hepatitis delta virus attachment receptors.Activation and regulation of purinergic P2X receptor channels Role of purinergic P2X receptors in the control of liver homeostasis.P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists Paroxetine suppresses recombinant human P2X7 responses Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis.Mechanisms for Hsp70 secretion: crossing membranes without a leader.Selective P2X(7) receptor antagonists for chronic inflammation and pain Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells.Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection.Current status of inflammasome blockers as anti-inflammatory drugs.P2X and P2Y nucleotide receptors as targets in cardiovascular disease.Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain.Pharmacological properties of the rhesus macaque monkey P2X7 receptor.R270C polymorphism leads to loss of function of the canine P2X7 receptor.CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation.Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.Mechanism of action of species-selective P2X(7) receptor antagonists.Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects Negative and positive allosteric modulators of the P2X(7) receptor.The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells.The Impact of Vitamin D3 Supplementation on Mechanisms of Cell Calcium Signaling in Chronic Kidney Disease.Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.Off-Target Anti-Inflammatory Activity of the P2X7 Receptor Antagonist AZ11645373.

P2860

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P2860

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.

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Characterization of a selectiv ...... P2X(7) receptors, AZ11645373.

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Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus

ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

Molecular physiology of P2X receptors

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Effects of antagonists at the human recombinant P2X7 receptor

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors

Complexities of measuring antagonist potency at P2X(7) receptor orthologs.

Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.

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