p53 stimulates human topoisomerase I activity by modulating its DNA binding.
about
Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.WRN protects against topo I but not topo II inhibitors by preventing DNA break formationComparative analysis of topoisomerase IB inhibition and DNA intercalation by flavonoids and similar compounds: structural determinates of activity.A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models.
P2860
p53 stimulates human topoisomerase I activity by modulating its DNA binding.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
p53 stimulates human topoisomerase I activity by modulating its DNA binding.
@en
type
label
p53 stimulates human topoisomerase I activity by modulating its DNA binding.
@en
prefLabel
p53 stimulates human topoisomerase I activity by modulating its DNA binding.
@en
P2860
P356
P1476
p53 stimulates human topoisomerase I activity by modulating its DNA binding
@en
P2093
Frank Grosse
P2860
P304
P356
10.1093/NAR/GKG846
P50
P577
2003-11-01T00:00:00Z