Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.
about
Inflammatory bowel disease reveals the kinase activity of KSR1KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel diseaseSimulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilinTumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis.hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cellsLycopene enhances antioxidant enzyme activities and immunity function in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer ratsEnterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitisKSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis.Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer.ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survivalEpidermal growth factor receptor inhibits colitis-associated cancer in miceNetwork modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.Non-Hematopoietic β-Arrestin1 Confers Protection Against Experimental Colitis.Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammationTNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosisGenetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia.Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaBRole of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury.Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.Going for broke: targeting the human cancer pseudokinome.Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk.KSR1 regulates BRCA1 degradation and inhibits breast cancer growth.The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ productionSoluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.Kinase suppressor of Ras transphosphorylates c-Raf-1.praja2 regulates KSR1 stability and mitogenic signalingThe ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF.KSR1 is required for cell cycle reinitiation following DNA damage.Positive impact of blocking tumor necrosis factor alpha on the nutritional status in pediatric Crohn's disease patients.The N-terminal kinase suppressor of Ras complex has a weak nucleoside diphosphate kinase activity.Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1.
P2860
Q24562733-16A2E158-CBE7-486E-B0A0-76DC4D004DADQ24626430-9DFE52E6-ED68-4B05-9B9F-297E8A6C28C9Q27027630-CDB1CD28-774B-4A4F-AD5D-4DE6CC30E566Q28476397-3D4B08DB-BFAE-427F-8A1D-B337A4ED2DEEQ30436649-60D13693-89C6-49F6-9F61-C6A7519BCD18Q33364397-67BFDD10-EB13-44D7-822E-530F16730CD8Q33607948-C61C5907-0112-4347-871B-A43D06345ADCQ33622860-19333365-600F-4AA1-9135-82C2E190202DQ34630392-6DD9B0DA-16BB-4E57-AFE0-F2FCC10D7E96Q34729456-287203C6-6F7B-4471-9627-AFD923150B87Q34805471-053C0AE8-8BAB-44E9-B55C-834FDD22CF2FQ35659991-56CB6D2B-ED97-49D6-8CBC-29E219B32770Q35675264-7E9899E8-A862-4AE3-9EB1-1D2B33A7ECF9Q35788383-BF0A19DA-7F79-4888-8FBC-25EF80FA4EF4Q36129106-B2814351-7F32-4D65-927D-91042E6FEBDCQ36134211-02E04416-720E-4100-B823-6E271053B91FQ36505726-5CD10E47-352F-4D02-A3E9-63438934D961Q36891517-09525596-3574-4F16-8E9E-D19FB311EDC9Q36944803-0D30C373-755A-48DF-B301-0A71D04B5686Q36954611-8283AD6C-FB81-4EB2-A747-707FA8182C31Q36961409-5B84CFAC-4A53-48F0-8626-C8D86E81C5B2Q37094120-67690517-DAAE-417E-914E-586A6F964A8EQ37136132-BE703C83-BB16-4898-8076-612E6F036B7EQ37617010-BB019B89-83C0-4243-93F6-17828EB7BE93Q37657176-8C7588F5-4E09-4B5E-B607-1C54F290759BQ38307398-D00884BF-5153-48F9-A3FB-4FDB337BDD01Q38953696-71B20538-8E8C-4890-BF7E-C4B7C9223D70Q38987139-9E4465C6-5D31-485A-9B32-AC2448523E5DQ39276410-E118A64E-D6DB-4E8D-AD56-34D122B82CD6Q39878562-1B4C5846-907A-4371-BD77-2ED96158C660Q39968515-16C36C72-253E-4D54-BD27-A1E5BF8970ACQ41417837-6BD98B07-65E2-4C66-A967-53D3EB3DC82AQ41863620-3CF4FA38-A486-4AAB-8DEC-885A2F970D93Q42058655-494D28D4-A71A-4266-8F8B-AE7C324A92E5Q42563084-E3DEADD4-7DE8-4273-9319-86C87C89184AQ42931128-6068CE4F-1BA6-405D-95ED-1EE2629799CAQ43167066-D9EC473D-8806-46C2-A7B2-584F7D27A1B6Q46362924-754EF57A-19C1-4783-B893-26DCC6A3D92BQ46633173-1143DF2E-FB88-49FA-B908-D3731DD953A3Q51981534-8237B0BB-1E09-4F25-884F-3B843DBBDDA7
P2860
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Kinase suppressor of Ras-1 pro ...... apoptosis during inflammation.
@en
type
label
Kinase suppressor of Ras-1 pro ...... apoptosis during inflammation.
@en
prefLabel
Kinase suppressor of Ras-1 pro ...... apoptosis during inflammation.
@en
P2093
P2860
P356
P1476
Kinase suppressor of Ras-1 pro ...... apoptosis during inflammation.
@en
P2093
D Brent Polk
David S Jones
Guinn Wilson
M Kay Washington
Sutha K John
P2860
P304
P356
10.1172/JCI200421022
P407
P577
2004-11-01T00:00:00Z