The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
about
NUP98 dysregulation in myeloid leukemogenesisHigh levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming eventCandidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid LeukemiaNUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report.NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsKnock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse modelIncreased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HDMouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia.Nuclear pore proteins and cancerFLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia.The role of HOX genes in normal hematopoiesis and acute leukemia.Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia.A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells.MLL is essential for NUP98-HOXA9-induced leukemia.Upregulation of Flt3 is a passive event in Hoxa9/Meis1-induced acute myeloid leukemia in mice.HOX proteins and leukemia.NUP98-HOXA9 bearing therapy-related myeloid neoplasm involves myeloid-committed cell and induces HOXA5, EVI1, FLT3, and MEIS1 expression.A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.Role of NOX2 for leukaemic expansion in a murine model of BCR-ABL1(+) leukaemia.NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.High expression of FLT3 is a risk factor in leukemia.
P2860
Q28298423-FF7D1F71-86D1-4999-B61B-9F03D156610CQ28299462-C94DDF1D-6F63-4EBD-87C2-68193281F64CQ33294832-D0A045D4-DDF4-46B5-A141-B12C37A9039AQ33558976-1E88FCB6-2EAB-40C5-AAB2-7432D8087FE1Q34318490-D85DBDD3-C6D2-4103-9DED-B3C4FED3AEF1Q35608150-8F5E3002-6AB9-416B-9FE4-A1A5B0A121E7Q35891637-68A24BD2-8853-487B-A36D-5296B6FBF5A4Q35892883-095EC37F-C28B-4064-A055-B064AD14C6DBQ36116636-2DC89C2F-654C-4CF1-82C9-99093F9FB72AQ36392936-2C3BBB4D-6C51-4737-8F0B-FB91BB040277Q36599294-03F59ED7-8AB8-47A0-849D-B35E0B01A8C9Q37170146-1AAF515E-B205-4B38-B92F-83B4352614E3Q37252910-E3642D18-37AF-4145-B9A4-6AB9D89CB428Q37460343-2E0D6AA7-3ABB-4030-9823-D9DC43DA0E74Q37647046-8A412BD6-7188-47EF-B78A-1568B28BBA4BQ38065068-86E59ED6-C1E9-4166-9749-53EE30550B7EQ38262122-9B948C24-707A-41F1-A7DF-23F42562B88DQ38720331-065D36BE-2168-4CC5-848D-9D8CA60B6EF3Q38882990-C0900EC0-EECC-4CF9-A056-E4FBED55BF97Q38956367-4AD8BCFB-4824-4ABE-96B4-7D06EAD4B244Q40586066-D13EBDC2-FD5E-4167-8AEB-6F18A3AA8497Q40797140-CC97FA9F-B751-4FFC-8E78-440D0AE7105EQ41291574-E5E0B211-6094-47CE-8783-C2EC7E2AA6EEQ42593097-4D85DC88-F0A2-4D2C-8D7F-87032E9C47B9Q46361008-937D740C-B0DE-4D44-B9EB-BE16DF0EF748Q46679237-8CDF3565-DF05-4147-988A-9BB3059BD2A1Q47283332-547BC7B7-40F9-41B1-86D7-7B444028C8B5
P2860
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The Flt3 receptor tyrosine kin ...... ons in acute myeloid leukemia.
@en
type
label
The Flt3 receptor tyrosine kin ...... ons in acute myeloid leukemia.
@en
prefLabel
The Flt3 receptor tyrosine kin ...... ons in acute myeloid leukemia.
@en
P2093
P1433
P1476
The Flt3 receptor tyrosine kin ...... ons in acute myeloid leukemia.
@en
P2093
Adrian Wan
Bob Argiropoulos
Carolina Abramovich
Gerald Krystal
Lars Palmqvist
Nicolas Pineault
P304
P356
10.1182/BLOOD-2005-12-007005
P407
P577
2006-08-01T00:00:00Z