Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice.
about
Meiotic transmission of an in vitro-assembled autonomous maize minichromosomeA new generation of human artificial chromosomes for functional genomics and gene therapyA highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin geneA pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challengesNovel method to load multiple genes onto a mammalian artificial chromosomeHAC stability in murine cells is influenced by nuclear localization and chromatin organization.Bi-HAC vector system toward gene and cell therapyHuman artificial chromosome with a conditional centromere for gene delivery and gene expression.Genetically modified pigs produced with a nonviral episomal vector.De novo assembly of potential linear artificial chromosome constructs capped with expansive telomeric repeatsGenerating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.Human artificial chromosomes for gene delivery and the development of animal modelsRetargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere.Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression.HACking the centromere chromatin code: insights from human artificial chromosomes.Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology.De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.Using human artificial chromosomes to study centromere assembly and function.Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster.Construction of rice mini-chromosomes by telomere-mediated chromosomal truncation.Manipulating transgenes using a chromosome vectorA novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21.
P2860
Q21145224-0CF58D1A-7162-42D7-AF90-80080C9FBE28Q24599954-1CB55DE2-1804-47AB-8EF3-7F2D64443E2AQ24631410-300931BC-AD98-41B3-9C92-DE7D3A513EA9Q26824073-D8AF065A-89CF-408E-B534-8EEC639EDD0FQ28538734-1E6F231A-AE48-4D6B-A608-E82B4C1C48E2Q33415674-7CB56816-F074-4BAE-B15B-E252FF993EECQ34065124-1D1C972B-C09B-47D5-BDED-AF27B573A85EQ34203410-2E2B60D7-609F-4749-AF3D-04670A708449Q34581389-D2B41BFC-CC57-4D94-89EF-FA897BC09651Q35005797-52D7D665-96A5-4901-8DFD-05A9676B270FQ35119065-0A79C2F8-BBA5-45C3-94BA-C77555DC093FQ35238272-4070D8E3-8C6C-4153-A355-945E8C082330Q35667864-3F27D2E0-5CB8-47C7-A8A0-F01C5050E3AAQ35786063-3C6B8658-0EDF-48D1-9686-B9F64463286FQ36600249-31887ACE-1027-45A9-9E6F-9D750A872535Q36878392-8A0D813A-F4E2-4DDF-9747-745D57BA27C3Q37981217-FD025AD6-D0A8-4294-9287-C76670E933E9Q38028807-9ED17717-9C22-4039-A64D-EB9ADBB28839Q38183464-FE6FAF7D-707E-417B-88BF-8479F9D20969Q38321960-B47C03F7-C0FA-478F-A797-B451829A5029Q39422214-CA744B0B-29D8-4961-9FAA-41EEA211B73DQ39557275-CDECCB30-325A-437B-88A5-5C52728EA350Q39661141-69D67DE2-37FA-44BF-A1F3-ADB389FEE3CDQ41845094-1A4C16CF-335A-4535-A9D4-D97F8BDB183AQ44500883-AB9AF879-F41A-409B-9F85-D0530B21B07D
P2860
Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Human artificial chromosomes c ...... transmissible to progeny mice.
@en
type
label
Human artificial chromosomes c ...... transmissible to progeny mice.
@en
prefLabel
Human artificial chromosomes c ...... transmissible to progeny mice.
@en
P2093
P2860
P356
P1476
Human artificial chromosomes c ...... transmissible to progeny mice.
@en
P2093
Kazuhiro Nishii
Masashi Ikeno
Nobutaka Suzuki
Tuneko Okazaki
P2860
P304
26615-26623
P356
10.1074/JBC.M603053200
P407
P577
2006-07-12T00:00:00Z