BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
about
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor proteinStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsDissecting Alzheimer disease in Down syndrome using mouse modelsA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeThe anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complexPMEL Amyloid Fibril Formation: The Bright Steps of Pigmentationβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseA tale of two drug targets: the evolutionary history of BACE1 and BACE2RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal ApoptosisCytoskeletal pathologies of Alzheimer diseaseInhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.BACE1 and BACE2 enzymatic activities in Alzheimer's disease.β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.Down-regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke.Two novel DNA motifs are essential for BACE1 gene transcriptionRegulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.Transcriptional Regulation of TMP21 by NFAT.The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionPrion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.Opportunities and Limitations of Modelling Alzheimer's Disease with Induced Pluripotent Stem Cellsβ-Secretases, Alzheimer's Disease, and Down Syndrome.Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.BACE2 expression increases in human neurodegenerative disease.Identification of BACE2 as an avid ß-amyloid-degrading proteaseThe Alzheimer's disease beta-secretase enzyme, BACE1.Regulation of global gene expression and cell proliferation by APPInhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease.Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome.Alzheimer's disease in people with Down's syndrome: the prospects for and the challenges of developing preventative treatmentsLentiviral vector-mediated gene transfer and RNA silencing technology in neuronal dysfunctions.Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease.Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems.Actin dynamics and cofilin-actin rods in alzheimer disease.Upregulation of SET expression by BACE1 and its implications in Down syndrome.Preventing expression of the nicotinic receptor subunit α7 in SH-SY5Y cells with interference RNA indicates that this receptor may protect against the neurotoxicity of Aβ.
P2860
Q24296758-2E8B0778-58F1-46BC-B811-854239F904A5Q26740189-5E0F81AA-3EE9-4688-A5DE-10E8CBFCD55FQ26777254-05776DCB-3749-439A-8DC5-33F84DB79805Q26798983-77DBE4BB-FF22-4B83-A6CB-21942EB009CDQ27319458-3748C957-7426-4474-B107-03461619FFD1Q28076932-F0CE99DB-2C08-4C15-8A79-541D88CE3172Q28245473-07571DD4-58D7-4088-9104-C27B777759FEQ28661086-C1575108-6801-44D1-AE8C-768CEAB0CE48Q29541602-8A8C5EB3-905A-4FF4-A615-1972DBD29498Q30435267-F23DE084-65E8-49AF-A1B6-C15759A5F152Q30530899-0D4A0DD3-20A9-444A-B256-848FF84AEFB0Q33643141-8467F520-86D4-4918-BB9F-B95F2BF0E745Q33947055-C63329DF-F023-4C07-BBFF-84E6674E7413Q34365603-ADC9BDD8-18F4-4631-A0BB-BF59B2707F93Q34431390-CFA7B355-6B4B-4A94-8572-B730902B30F6Q34685048-96C2C786-5C02-48BD-A103-7C3B4EF01F86Q34716366-AD32C340-C4D1-46ED-9AE8-5154C76D86FDQ34764030-56200C03-E00E-4D6B-8E06-F472ED1129FDQ35214758-8D3014F4-245A-436C-8155-A9D92A84D2D4Q35313016-5B29DD15-DEEB-4464-A90A-1B355B1B9D66Q35750557-9CE5FEFE-2097-43DF-85A9-045C4ECCE51CQ35821455-8E058AA9-977D-43DF-B1D1-53253BD0393FQ35913113-98B104BA-C994-4B0F-9416-12EACB50907DQ35917682-AE108628-4D01-49C3-A789-88F6B7107EFDQ36316174-CE76B8D5-1B6C-4615-B59C-9698688098F8Q36397690-C8170023-B77E-43DE-AEBE-97BAC8594D42Q36645356-4FA0D25C-3E43-459D-AD5E-D9BB5B229E34Q36869427-286A5E2F-4CF5-4F3A-B420-4EA2A8A685BBQ36967843-8207373B-125C-4D86-A31D-7029F6480400Q37108142-4B335D58-2EE4-41B1-AA49-25E12A124742Q37169151-3BACBA0C-9A91-428C-BC31-5D82436241BBQ37415153-54C31561-59E4-4BAA-BAAF-6ECB4347BF51Q37671444-C0D3FA5D-3EEF-4B9F-A335-CBA8E036BF8AQ37730984-A371AAE2-EC6D-44FA-B005-CC390FBA758AQ37791489-76991214-13FF-4D7A-B61A-1B0604E5531EQ37961881-0AB73A28-CC9F-48E2-A87C-D284F87206A7Q38002193-4CE9C149-D350-4ACB-AB1B-8CF06D772451Q38731927-1631DA22-7FF0-4E37-ACC7-121ADD82043EQ38984026-832D68AB-D56A-46AB-AABF-7892FEF893B4Q39190582-1A4439A3-A6FC-476E-A4D7-9022C47348E6
P2860
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
BACE2, as a novel APP theta-se ...... er's disease in Down syndrome.
@en
type
label
BACE2, as a novel APP theta-se ...... er's disease in Down syndrome.
@en
prefLabel
BACE2, as a novel APP theta-se ...... er's disease in Down syndrome.
@en
P356
P1433
P1476
BACE2, as a novel APP theta-se ...... er's disease in Down syndrome.
@en
P2093
Guiqiong He
Xiulian Sun
P304
P356
10.1096/FJ.05-5632COM
P407
P50
P577
2006-07-01T00:00:00Z