Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
about
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesisRecent advances in understanding and managing cholestasisBile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerFXR signaling in the enterohepatic systemDiscovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasisBile acid nuclear receptor FXR and digestive system diseasesBile acid signaling in metabolic disease and drug therapyFarnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivoFXR regulates liver repair after CCl4-induced toxic injuryFarnesoid X Receptor an Emerging Target to Combat Obesity.Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats.Clinical application of transcriptional activators of bile salt transporters.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.Targets for current pharmacologic therapy in cholesterol gallstone disease.Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null miceEndocrine functions of bile acids.Deciphering the nuclear bile acid receptor FXR paradigm.Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.Tissue-specific function of farnesoid X receptor in liver and intestineBenefit of farnesoid X receptor inhibition in obstructive cholestasis.Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity.Evaluation of 11C-acetate and 18F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma.New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated RatsThe enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts.Therapy of gallstone disease: What it was, what it is, what it will beOrganic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injuryBile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.Intravenous Lipid Emulsions in Parenteral NutritionFXR and liver carcinogenesisNovel insight into mechanisms of cholestatic liver injury.
P2860
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P2860
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Hepatoprotection by the farnes ...... and extrahepatic cholestasis.
@en
type
label
Hepatoprotection by the farnes ...... and extrahepatic cholestasis.
@en
prefLabel
Hepatoprotection by the farnes ...... and extrahepatic cholestasis.
@en
P2093
P2860
P356
P1476
Hepatoprotection by the farnes ...... and extrahepatic cholestasis.
@en
P2093
Bhasha Desai
Bryan Goodwin
Guizhen Luo
Kathleen I MacKenzie
Mary Jo Numerick
Stacey A Jones
Steve Dennis
Steven A Kliewer
Traci A Mansfield
P2860
P304
P356
10.1172/JCI18945
P407
P577
2003-11-17T00:00:00Z