Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
about
Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanismsA novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct foldingWeight-independent effects of roux-en-Y gastric bypass on glucose homeostasis via melanocortin-4 receptors in mice and humans.Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexiaGenetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regionsRecent progress in the genetics of common obesityBrain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.From monogenic to polygenic obesity: recent advances.Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.Obesity-linked variants of melanocortin-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone.Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4RSynthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.Chapter 15: disease gene prioritization.Comprehensive in silico mutagenesis highlights functionally important residues in proteins.In silico mutagenesis: a case study of the melanocortin 4 receptorIdentification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).Molecular basis of obesity: current status and future prospectsLong-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study groupGene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.Molecular genetic aspects of weight regulation.Melanocortin signaling in the brainstem influences vagal outflow to the stomach.Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.Mouse models for the central melanocortin system.Neural melanocortin receptors in obesity and related metabolic disorders.Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize.Progress in the genetics of common obesity and type 2 diabetes.Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes.Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective.Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.
P2860
Q27000617-8D6AE888-F9D5-4AB7-A340-4C937D0992D9Q28484335-D6955571-AE5E-47EF-871C-1F12CB6C9932Q30416281-9ABB9164-26F7-4C4E-A452-A0B590A1C0CAQ33326337-0C1E0C5F-6973-426B-A6D8-584FE437F4D2Q33599821-A374125A-68DE-44C0-927A-EE5B5D93C8E0Q33607966-A8135F0B-9991-4D51-821E-5E713CD21861Q33662901-B6CB2701-275C-4C06-9E62-58E0AF1A85D3Q33669634-BB2EEC30-2EC2-4FFE-9BFA-520C9C4595F3Q33731455-7D2419A9-EECA-4CF9-8DFB-6BABE2CC5B2BQ33750073-B135D348-E465-452E-8260-2470E8CA474AQ34132264-211C2D5E-61DC-45FA-9613-E35563EDACD2Q34215680-68E65383-9403-40A7-B64B-1163CC89C07CQ34343356-1942FC0F-8C2F-49BF-82D3-BC886D95FFA3Q34523677-A98A6650-B710-4E3D-A488-C13164100E7DQ34631536-01647619-2813-47B9-99C2-7246BC105A18Q34697737-3FE04632-166D-4ED9-B5FA-322B46D8B81AQ34806039-C70F6BA7-0859-405F-AEC0-8CD54B1FD67DQ34979349-98BB704A-1660-4728-87D3-011D10F0E8A8Q35092040-317C3673-839B-4D01-9AF4-46EB62C269A4Q35107257-0D721E76-3170-487A-AC98-F50B1336DDF3Q35140411-70BB2FB7-D801-4FB7-9960-C2CD952D07D6Q35597958-8967B725-5929-4BF3-B2D4-3E1485939BE4Q36003378-A50245A1-70FA-4053-AE94-3732E49A1CF6Q36232983-A43AEB32-BA74-4F2F-9366-A730DE5415AFQ36447401-973AF433-E62E-4D45-9E46-5DE5415066E2Q36467059-0143AAB8-6475-499F-BF1D-C6273B411A1BQ36842656-7D4D7B83-8AB9-41A5-8A0F-C76A5B4DEFEAQ36904053-557EA733-B996-48EC-B400-FC876D8C12FCQ37093842-5A9DDD87-314F-46D8-B9BA-E05D119BDA39Q37157903-2E0FEAD5-6972-4A83-A441-7FE8B6D972ECQ37196255-37B1841F-5A00-492A-8F15-F07D004D72A7Q37213116-20C0F051-5F85-49D0-9662-27AB28DF7541Q37284868-9AFA8DBB-1EAD-43CE-9541-50CDD101323CQ37319610-845B5886-4883-4D59-B707-7235377A0965Q37377496-DFDECC1B-03DF-4096-8680-07479E3F2D14Q37698685-58BE9DC7-7155-4C43-8F1E-F8CC11A8B7E3Q37760961-0396E778-5878-4288-8381-AB25CAFF8656Q38071008-2B2BF9F3-2262-4E19-B669-2DA8B7A2EC43Q39704718-DD695D92-6031-475D-9DC9-B15E622CA873Q41165076-E9DB8423-77A2-4487-B587-00011003B2CD
P2860
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Pharmacological characterizati ...... ted protein (AGRP) antagonist.
@en
type
label
Pharmacological characterizati ...... ted protein (AGRP) antagonist.
@en
prefLabel
Pharmacological characterizati ...... ted protein (AGRP) antagonist.
@en
P2093
P356
P1433
P1476
Pharmacological characterizati ...... ted protein (AGRP) antagonist.
@en
P2093
Amanda M Shaw
Bettina Proneth
Carrie Haskell-Luevano
Michael S Wood
Nicholas B Sorensen
Sally A Litherland
William J Millard
Zhimin Xiang
P304
P356
10.1021/BI0600300
P407
P577
2006-06-01T00:00:00Z