RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes.
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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancerOncogenic cooperation and coamplification of developmental transcription factor genes in lung cancerA gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Sykt10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repressionComplex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progressionGrowth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.Genome profiling of ERBB2-amplified breast cancers.An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature.Relationships linking amplification level to gene over-expression in gliomasGenomic instability in breast cancer: pathogenesis and clinical implicationsSMURF1 amplification promotes invasiveness in pancreatic cancer.High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancerEGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.Role of Erbin in ErbB2-dependent breast tumor growth.Progress towards the development of SH2 domain inhibitors.Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.A kinase shRNA screen links LATS2 and the pRB tumor suppressorGPHMM: an integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arraysActivation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3BFunctional characterization of the 19q12 amplicon in grade III breast cancersGrb7 gene amplification and protein expression by FISH and IHC in ovarian cancer.Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells.High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer.Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expressionGenomic organization and control of the grb7 gene family.HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression.Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesisRegularized Multivariate Regression for Identifying Master Predictors with Application to Integrative Genomics Study of Breast Cancer.Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers.Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancerDNA amplifications in breast cancer: genotypic-phenotypic correlations.The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies.The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells.Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.
P2860
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P2860
RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
RNA interference-based functio ...... ribution of coamplified genes.
@en
type
label
RNA interference-based functio ...... ribution of coamplified genes.
@en
prefLabel
RNA interference-based functio ...... ribution of coamplified genes.
@en
P356
P1476
RNA interference-based functio ...... ribution of coamplified genes.
@en
P2093
Jessica Kao
P2860
P304
P356
10.1002/GCC.20339
P577
2006-08-01T00:00:00Z