Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein.
about
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteinsHDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophyScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinThe Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesiGanglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease miceDetection of alpha-rod protein repeats using a neural network and application to huntingtin.Huntingtin facilitates polycomb repressive complex 2.Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.The Huntington's disease-related cardiomyopathy prevents a hypertrophic response in the R6/2 mouse model.Therapeutic approaches to preventing cell death in Huntington diseaseLocation trumps length: polyglutamine-mediated changes in folding and aggregation of a host proteinDevelopment of an ELISA assay for the quantification of soluble huntingtin in human blood cells.HD CAG-correlated gene expression changes support a simple dominant gain of function.Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14LDysfunction of the CNS-heart axis in mouse models of Huntington's disease.Native mutant huntingtin in human brain: evidence for prevalence of full-length monomerFolding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteinsElongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans.Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function.Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathologyPost-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington's Disease.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Huntingtin polyQ Mutation Impairs the 17β-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.The cryo-electron microscopy structure of huntingtin
P2860
Q21144909-7CBAA16B-9C92-4221-A57B-DE944E3EBC76Q24613607-77056421-5813-4CCB-AE1E-E18375E68757Q27311425-8F55F2F7-E7E5-46A3-97FA-CA8150703A61Q28544898-6155DC21-7F75-4DE5-8506-3D98DDA98558Q28571426-27FE0E49-A634-40E2-9061-F4ECB2465BC2Q30423904-D8084B2D-B84B-4421-9FA0-57FA6985C8DEQ30506469-537C9B95-DFDE-4DE7-9997-E57131A4681DQ33417634-B6D0F7DB-2F15-47EF-AF5D-6307DF54E336Q33594204-6604801C-814D-4E98-8F2E-581680EA3921Q34189409-5988D65B-F740-431B-9394-9BCB8A2D5F02Q34274478-09769384-FBC5-4792-81BB-24D6C9CF7238Q34277801-72E8A466-48A3-41D9-A752-9C4BFA754E30Q34411338-F4A5E0F2-ACF1-4C42-9012-9B430F07C193Q35051262-5CEDDB07-C249-4FB3-95CF-CD678B50932DQ35052612-A99A4632-E675-4F0F-94E2-E04426AFFCF0Q35056067-2FA1C489-D9AF-459A-8DD0-9825EF1C2C07Q35126285-13536E2B-9988-4AC9-9169-861E1C993E7EQ35220835-8D7D3C94-04E6-43AB-ABD7-CA1A28D8A921Q35921703-A974AC76-5A93-40B4-8F0C-6FB7A0AD93FFQ36043574-6465AF34-CD68-45E6-8604-412F41E9BE6FQ36098669-78B01BBE-BD6F-48B9-B342-C7062F3080D7Q36688900-E352DC6D-D22E-4D2C-98DE-530A8F25E05BQ36746987-9A2ECEF3-D8F4-4176-9EDC-2A83E771BEAFQ36839701-D24C1F4C-E045-4F81-A382-89260EB61765Q37839534-3C001360-1D93-43E8-885F-B2FD328FE4A6Q37969749-59CB7C15-004B-4F2C-9497-6AD6255FD6DEQ38374920-058E7001-125C-4FF8-BACB-EB85EE813576Q38681978-EB6E51EB-F1FB-4EDF-97D9-AE645D2F674DQ39035495-E29938D4-CE5C-4FA4-88D0-55C97D6150E0Q39106346-66E3BDA4-A9C9-4E2E-A4D3-8E8F65FA4B02Q39124557-BD2A8A9F-6185-4902-A340-6DE53BD37A4BQ41880469-034F70FE-3B74-4D9B-85C6-8A81B62497ADQ52162415-DF31FE56-A5BA-4727-B4D8-49972E94FEE8
P2860
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Expression and characterizatio ...... elongated HEAT repeat protein.
@en
type
label
Expression and characterizatio ...... elongated HEAT repeat protein.
@en
prefLabel
Expression and characterizatio ...... elongated HEAT repeat protein.
@en
P2093
P2860
P356
P1476
Expression and characterizatio ...... elongated HEAT repeat protein.
@en
P2093
David C Rubinsztein
James A Huntington
Wendy J Carter
P2860
P304
15916-15922
P356
10.1074/JBC.M511007200
P407
P577
2006-04-04T00:00:00Z