Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
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Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cellsThe genetic architecture of adaptations to high altitude in EthiopiaOxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2Non-small cell lung cancer: identifying prognostic imaging biomarkers by leveraging public gene expression microarray data--methods and preliminary resultsHypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinomaHIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogasterREST is a hypoxia-responsive transcriptional repressorInhibition of 2-oxoglutarate dependent oxygenasesManganese-mediated acceleration of age-related hearing loss in mice.Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cellsProlonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cavaActivation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytesMitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxiaHypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.Hypoxic enhancement of exosome release by breast cancer cells.HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cellsIntegrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.Gene expression module-based chemical function similarity search.Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.Massive transcriptional start site analysis of human genes in hypoxia cells.Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1The VHL-dependent regulation of microRNAs in renal cancer.In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer.Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha.Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop.Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.Hypoxia regulates alternative splicing of HIF and non-HIF target genes.Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells.Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockadeCooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regionsDeficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney functionHypoxia represses microRNA biogenesis proteins in breast cancer cells.Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
P2860
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P2860
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Concordant regulation of gene ...... IF-2alpha, and other pathways.
@en
type
label
Concordant regulation of gene ...... IF-2alpha, and other pathways.
@en
prefLabel
Concordant regulation of gene ...... IF-2alpha, and other pathways.
@en
P2093
P356
P1476
Concordant regulation of gene ...... IF-2alpha, and other pathways.
@en
P2093
Gareth P Elvidge
Jiannis Ragoussis
Louisa Glenny
Rebecca J Appelhoff
P304
15215-15226
P356
10.1074/JBC.M511408200
P407
P577
2006-03-24T00:00:00Z