S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.
about
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cellsPlk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanismsAllosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5Pathway of ATP hydrolysis by monomeric kinesin Eg5Life and times of a cellular blebStable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpointThe deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cellsSpatial Compartmentalization Specializes the Function of Aurora A and Aurora B.TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acidAn allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complexThe Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium ChlorideOptimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft ModelsTriphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor ActivitySmall molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapyCdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinementMyo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division.PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis.Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.Xenopus oocyte meiosis lacks spindle assembly checkpoint control.Development of a Drosophila cell-based error correction assay.EGF-induced centrosome separation promotes mitotic progression and cell survival.Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics.Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.Eg5 restricts anaphase B spindle elongation in mammalian cells.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesIdentification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approachEfficient size-independent chromosome delivery from yeast to cultured cell linesOpposite-polarity motors activate one another to trigger cargo transport in live cellsQuantification of surface tension and internal pressure generated by single mitotic cells.Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment.Mechanical control of mitotic progression in single animal cells.A genomic toolkit to investigate kinesin and myosin motor function in cells.Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.Sensors at centrosomes reveal determinants of local separase activity.
P2860
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P2860
S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.
@en
type
label
S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.
@en
prefLabel
S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.
@en
P2093
P2860
P50
P356
P1476
S-trityl-L-cysteine is a rever ...... lly blocks mitotic progression
@en
P2093
David Hackney
Dimitrios A Skoufias
Isabelle Crevel
Richard H Wade
Salvatore DeBonis
Yasmina Saoudi
P2860
P304
17559-17569
P356
10.1074/JBC.M511735200
P407
P577
2006-02-28T00:00:00Z