S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. - Wikidata - wikimedia - TriplyDB

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

http://www.wikidata.org/entity/Q40310383

about

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5 Pathway of ATP hydrolysis by monomeric kinesin Eg5 Life and times of a cellular bleb Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B.TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride Optimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5 Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division.PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis.Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.Xenopus oocyte meiosis lacks spindle assembly checkpoint control.Development of a Drosophila cell-based error correction assay.EGF-induced centrosome separation promotes mitotic progression and cell survival.Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics.Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.Eg5 restricts anaphase B spindle elongation in mammalian cells.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach Efficient size-independent chromosome delivery from yeast to cultured cell lines Opposite-polarity motors activate one another to trigger cargo transport in live cells Quantification of surface tension and internal pressure generated by single mitotic cells.Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment.Mechanical control of mitotic progression in single animal cells.A genomic toolkit to investigate kinesin and myosin motor function in cells.Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.Sensors at centrosomes reveal determinants of local separase activity.

P2860

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P2860

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

http://www.wikidata.org/entity/Q40310383

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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name

S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.

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S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.

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S-trityl-L-cysteine is a rever ...... ly blocks mitotic progression.

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P1433

Journal of Biological Chemistry

P1476

S-trityl-L-cysteine is a rever ...... lly blocks mitotic progression

@en

P2093

David Hackney

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Dimitrios A Skoufias

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Isabelle Crevel

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Richard H Wade

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Salvatore DeBonis

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Yasmina Saoudi

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P2860

CENP-E is a putative kinetochore motor that accumulates just before mitosis

A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Cloning and expression of human mitotic centromere-associated kinesin gene

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

A standardized kinesin nomenclature

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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17559-17569

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scholarly article

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10.1074/JBC.M511735200

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P433

26

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P478

281

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Frank Kozielski

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2006-02-28T00:00:00Z

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7269390

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16507573

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