MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
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Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 214-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationNedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptorhSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomasDifferential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosisRibosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionN-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasomeProteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28 -Dependent MechanismExamination of the expanding pathways for the regulation of p21 expression and activity.Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycleAciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivoThe intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathwayRapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyA regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells.14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome.MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.Regulation of p53-MDMX interaction by casein kinase 1 alpha.MDM2 mediates ubiquitination and degradation of activating transcription factor 3Regulating the 20S proteasome ubiquitin-independent degradation pathway.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasionU-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha.Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndromeScreening E3 substrates using a live phage display libraryA p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferationAging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expressionStress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct waysUbiquitin-independent proteasomal degradation during oncogenic viral infections.MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells.The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance.Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrestUbiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsUbiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletionUbiquitin ligases in malignant lymphoma.Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications.
P2860
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P2860
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
@en
type
label
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
@en
prefLabel
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
@en
P2093
P2860
P356
P1433
P1476
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation.
@en
P2093
Hunjoo Lee
Mu-Shui Dai
Shelya X Zeng
P2860
P304
P356
10.1093/EMBOJ/CDG600
P407
P577
2003-12-01T00:00:00Z