Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins
about
Mechanical properties of lipid bilayers and regulation of mechanosensitive function: from biological to biomimetic channelsA new view of the lethal apoptotic poreBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisBax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranesActive fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergenceStructure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.Pro-apoptotic Bax molecules densely populate the edges of membrane pores.The use of therapeutic peptides to target and to kill cancer cells.The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption.Assembling the puzzle: Oligomerization of α-pore forming proteins in membranesµ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis.Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.A lipocentric view of peptide-induced pores.Deficiency of the Bax gene attenuates denervation-induced apoptosisMolecular basis for membrane pore formation by Bax protein carboxyl terminusBax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.Rational development of a cytotoxic peptide to trigger cell death.Ovarian aging and menopause: current theories, hypotheses, and research models.The Bax pore in liposomes, Biophysics.Conformational changes and protein stability of the pro-apoptotic protein Bax.Bid: a Bax-like BH3 protein.The secrets of the Bcl-2 family.Mitochondrial channels: ion fluxes and more.Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes.Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model.Bax and Bak Pores: Are We Closing the Circle?Apoptotic foci at mitochondria: in and around Bax pores.Pore formation by dimeric Bak and Bax: an unusual pore?Equinatoxin II permeabilizing activity depends on the presence of sphingomyelin and lipid phase coexistenceProapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size.Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization processPores formed by Baxα5 relax to a smaller size and keep at equilibriumPore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.Influence of whole-body dynamics on 15N PISEMA NMR spectra of membrane proteins: a theoretical analysis.Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.Interaction of the alpha-helical H6 peptide from the pro-apoptotic protein tBid with cardiolipin.Effect of the structural difference between Bax-α5 and Bcl-xL-α5 on their interactions with lipid bilayers.BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.
P2860
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P2860
Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Peptides derived from apoptoti ...... he parent full-length proteins
@en
type
label
Peptides derived from apoptoti ...... he parent full-length proteins
@en
prefLabel
Peptides derived from apoptoti ...... he parent full-length proteins
@en
P2860
P50
P1433
P1476
Peptides derived from apoptoti ...... he parent full-length proteins
@en
P2093
Gianfranco Menestrina
Manuela Coraiola
P2860
P304
P356
10.1529/BIOPHYSJ.104.058008
P407
P577
2005-03-18T00:00:00Z