MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.
about
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulatorProteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathwayp38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisEffects of MdmX on Mdm2-mediated downregulation of pRBSuppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2MDM2 regulates dihydrofolate reductase activity through monoubiquitinationMdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanismHepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma ProteinProteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.PACT is a negative regulator of p53 and essential for cell growth and embryonic developmentRapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyA regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells.Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein HydrolysatesThe ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.Mdm2 facilitates the association of p53 with the proteasome.Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein.Epstein-Barr virus nuclear antigen 3A promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.Mechanism of p53 stabilization by ATM after DNA damage.Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein.Screening E3 substrates using a live phage display libraryTimely activation of budding yeast APCCdh1 involves degradation of its inhibitor, Acm1, by an unconventional proteolytic mechanism.E2F1-dependent oncogenic addiction of melanoma cells to MDM2.Ubiquitin-independent proteasomal degradation during oncogenic viral infections.A comprehensive method for detecting ubiquitinated substrates using TR-TUBE.MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells.hHR23B is required for genotoxic-specific activation of p53 and apoptosis.Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation.Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.
P2860
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P2860
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
MDM2 promotes proteasome-depen ...... ion of retinoblastoma protein.
@en
type
label
MDM2 promotes proteasome-depen ...... ion of retinoblastoma protein.
@en
prefLabel
MDM2 promotes proteasome-depen ...... ion of retinoblastoma protein.
@en
P2093
P1433
P1476
MDM2 promotes proteasome-depen ...... tion of retinoblastoma protein
@en
P2093
Donny L F Chang
Haoqiang Ying
Martin J Allday
Patima Sdek
Robert Touitou
Zhi-Xiong Jim Xiao
P304
P356
10.1016/J.MOLCEL.2005.10.017
P50
P577
2005-12-01T00:00:00Z