Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
about
Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolidesMarine pharmacology in 2005-2006: antitumour and cytotoxic compounds.Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatinThe quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryosDrugs that target dynamic microtubules: a new molecular perspectiveEfficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.A highly step-economical synthesis of dictyostatin.Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.Microtubule dynamics as a target in oncology.Porphyrins affect the self-assembly of tubulin in solution.Microtubule stabilising agents for cancer chemotherapy.New microtubule-inhibiting anticancer agents.The medicinal potential of promising marine macrolides with anticancer activity.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Recent advances in the diastereoselective Reformatsky-type reaction.An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.Highly Stereoselective Total Synthesis of (+)-9-epi-Dictyostatin and (-)-12,13-Bis-epi-dictyostatinRepositioning Microtubule Stabilizing Drugs for Brain Disorders
P2860
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P2860
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Tubulin assembly, taxoid site ...... tabilizing agent dictyostatin.
@en
type
label
Tubulin assembly, taxoid site ...... tabilizing agent dictyostatin.
@en
prefLabel
Tubulin assembly, taxoid site ...... tabilizing agent dictyostatin.
@en
P2093
P356
P1433
P1476
Tubulin assembly, taxoid site ...... stabilizing agent dictyostatin
@en
P2093
Andreas Vogt
Arndt M Brückner
Billy W Day
Brianne S Raccor
Charitha Madiraju
Dennis P Curran
Ernest Hamel
Jean-Hugues Fournier
Kenneth A Giuliano
Michael C Edler
P304
15053-15063
P356
10.1021/BI050685L
P407
P50
P577
2005-11-01T00:00:00Z