A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin.
about
The tell-tale heart: molecular and cellular responses to childhood anthracycline exposurep62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stressThe ubiquitin-proteasome system and cardiovascular diseaseTargeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategiesPriming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafilMitochondrial quality control in the myocardium: cooperation between protein degradation and mitophagyDiminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injuryAlpha B-crystallin suppresses pressure overload cardiac hypertrophyTranscription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte deathTranscriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat modelAging is not associated with proteasome impairment in UPS reporter mice.The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective.A mouse model for juvenile doxorubicin-induced cardiac dysfunctionProteasomal and lysosomal protein degradation and heart disease.Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy.Autophagy and the ubiquitin-proteasome system in cardiac dysfunction.Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytesOverexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicinPhysiological levels of ATP negatively regulate proteasome function.Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.).Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicityHepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in miceProteasome malfunction activates macroautophagy in the heart.Proteasome functional insufficiency in cardiac pathogenesis.Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubesGenetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice.COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.Desminopathies: pathology and mechanisms.Ubiquitin receptors and protein quality controlBreaking down protein degradation mechanisms in cardiac muscle.Cardiac systolic dysfunction in doxorubicin-challenged rats is associated with upregulation of MuRF2 and MuRF3 E3 ligasesHECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.Protein quality control and degradation in cardiomyocytes.The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.
P2860
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P2860
A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A novel transgenic mouse model ...... m in the heart by doxorubicin.
@en
type
label
A novel transgenic mouse model ...... m in the heart by doxorubicin.
@en
prefLabel
A novel transgenic mouse model ...... m in the heart by doxorubicin.
@en
P2093
P356
P1433
P1476
A novel transgenic mouse model ...... m in the heart by doxorubicin.
@en
P2093
Asangi R K Kumarapeli
Hanqiao Zheng
Jinbao Liu
Joseph W Glasford
Kathleen M Horak
Quanhai Chen
P304
P356
10.1096/FJ.05-3973FJE
P407
P50
P577
2005-09-27T00:00:00Z