Pharmacological characterization of human and murine neuropeptide s receptor variants.
about
Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107ISynthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonistsIn vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide SNeuropeptide S is a stimulatory anxiolytic agent: a behavioural study in miceNeuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdalaSynthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptorMolecular evolution of the neuropeptide S receptorNeuropeptide S: a novel modulator of stress and arousalExpression and function of NPSR1/GPRA in the lung before and after induction of asthma-like diseaseG protein-coupled receptor for asthma susceptibility associates with respiratory distress syndromeA novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in ratsNeuropeptide S-mediated facilitation of synaptic transmission enforces subthreshold theta oscillations within the lateral amygdalaPhylogenetic appearance of neuropeptide S precursor proteins in tetrapodsStructure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptorGenetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.Persistent nociception induces anxiety-like behavior in rodents: role of endogenous neuropeptide SIn vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors.Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startleAbnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801.Behavioral phenotyping of neuropeptide S receptor knockout mice.Genome-wide association of sleep and circadian phenotypes.Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritisIdentifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activityNeuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disordersImportance of extracellular loop one of the neuropeptide S receptor for biogenesis and functionNeuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthmaGenetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene.Molecular fingerprint of neuropeptide S-producing neurons in the mouse brain.The asthma candidate gene NPSR1 mediates isoform specific downstream signalling.Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide.Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation.Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain.Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivityNeuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli.Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathwaysIntranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one.
P2860
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P2860
Pharmacological characterization of human and murine neuropeptide s receptor variants.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Pharmacological characterization of human and murine neuropeptide s receptor variants.
@en
type
label
Pharmacological characterization of human and murine neuropeptide s receptor variants.
@en
prefLabel
Pharmacological characterization of human and murine neuropeptide s receptor variants.
@en
P2093
P356
P1476
Pharmacological characterization of human and murine neuropeptide s receptor variants.
@en
P2093
Joanne Zeng
Naoe Okamura
Olivier Civelli
Rainer K Reinscheid
Shinjae Chung
Yan-Ling Xu
Zhiwei Wang
P304
P356
10.1124/JPET.105.093427
P407
P577
2005-09-06T00:00:00Z