Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship
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The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdownMapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptidesThe Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.Isolation and preliminary characterization of herpes simplex virus 1 primary enveloped virions from the perinuclear spaceEffects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitroIdentification of an essential domain in the herpes simplex virus 1 UL34 protein that is necessary and sufficient to interact with UL31 protein.Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activityRole of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress.The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress.Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functionsMyosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteinsHerpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B.Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress.Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replicationU(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.p32 is a novel target for viral protein ICP34.5 of herpes simplex virus type 1 and facilitates viral nuclear egress.Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cellsHerpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells.US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosisGlycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.The UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions.Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cellsHerpes Simplex Virus 1 Recruits CD98 Heavy Chain and β1 Integrin to the Nuclear Membrane for Viral De-EnvelopmentRole of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear EgressNuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling.Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3.Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase.Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growth.Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membraneEpstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion productionTwo viral kinases are required for sustained long distance axon transport of a neuroinvasive herpesvirus.Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase.Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.Phosphorylation of the U(L)31 protein of herpes simplex virus 1 by the U(S)3-encoded kinase regulates localization of the nuclear envelopment complex and egress of nucleocapsids.Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitinationPlus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread.
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Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Herpes simplex virus type 1 pr ...... S3-UL34 catalytic relationship
@en
type
label
Herpes simplex virus type 1 pr ...... S3-UL34 catalytic relationship
@en
prefLabel
Herpes simplex virus type 1 pr ...... S3-UL34 catalytic relationship
@en
P2860
P1433
P1476
Herpes simplex virus type 1 pr ...... S3-UL34 catalytic relationship
@en
P2093
Brent J Ryckman
Richard J Roller
P2860
P304
P356
10.1128/JVI.78.1.399-412.2004
P407
P577
2004-01-01T00:00:00Z