Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
about
A conserved phosphatase cascade that regulates nuclear membrane biogenesisThe Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.Roles of phosphatidate phosphatase enzymes in lipid metabolismLipins, lipinopathies, and the modulation of cellular lipid storage and signalingThe cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity.Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemiaHomo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesityLipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factorsSumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulumConserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity.Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissueMicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) miceA hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the ratDual function lipin proteins and glycerolipid metabolismLipin proteins form homo- and hetero-oligomersInsulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesisAlterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.Nuclear export of the rate-limiting enzyme in phosphatidylcholine synthesis is mediated by its membrane binding domain.Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.KIT is required for hepatic function during mouse post-natal development.SRSF10 regulates alternative splicing and is required for adipocyte differentiationCharacterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion.Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathwayComplex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolismSequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.Identification of a novel lipin homologue from the parasitic protozoan Trypanosoma brucei.Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brainThe discovery of the fat-regulating phosphatidic acid phosphatase geneExpression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease
P2860
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P2860
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Alternatively spliced lipin is ...... ion, and role in adipogenesis.
@en
type
label
Alternatively spliced lipin is ...... ion, and role in adipogenesis.
@en
prefLabel
Alternatively spliced lipin is ...... ion, and role in adipogenesis.
@en
P2860
P356
P1476
Alternatively spliced lipin is ...... tion, and role in adipogenesis
@en
P2093
Miklós Péterfy
P2860
P304
32883-32889
P356
10.1074/JBC.M503885200
P407
P577
2005-07-27T00:00:00Z