Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.
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How genetic errors in GPCRs affect their function: Possible therapeutic strategiesN-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexiaBrain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsA small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.In silico mutagenesis: a case study of the melanocortin 4 receptorIdentification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditionsThe melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study groupPrevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transductionConstitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions.Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.Rescue of melanocortin 4 receptor (MC4R) nonsense mutations by aminoglycoside-mediated read-through.Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation.Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population.Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED).Appetite-Related Gut Peptides in Obesity and Binge Eating Disorder.A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population.Melanocortin-4 Receptor Gene Mutations in a Dutch Cohort of Obese Children
P2860
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P2860
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Functional analyses of melanoc ...... nd nonobese or obese subjects.
@en
type
label
Functional analyses of melanoc ...... nd nonobese or obese subjects.
@en
prefLabel
Functional analyses of melanoc ...... nd nonobese or obese subjects.
@en
P356
P1476
Functional analyses of melanoc ...... nd nonobese or obese subjects.
@en
P2093
Deborah L Segaloff
P304
P356
10.1210/JC.2005-0519
P407
P50
P577
2005-07-19T00:00:00Z