Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
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The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerUbiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingThe Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and DiseaseRole of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.Nck adapter proteins: functional versatility in T cellsThe Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.Stoichiometry and intracellular fate of TRIM-containing TCR complexes.Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expressionSLAP deficiency decreases dsDNA autoantibody productionCD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentCbl enforces Vav1 dependence and a restricted pathway of T cell developmentThe Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifsSrc-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.Normal T-cell development and immune functions in TRIM-deficient mice.SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modificationsSLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.Src-like adaptor protein regulates osteoclast generation and survival.Cbl enforces an SLP76-dependent signaling pathway for T cell differentiationGenome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cellsSLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells.Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model.Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory.Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface.Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.Post-translational control of T cell development by the ESCRT protein CHMP5.CD3ε recruits Numb to promote TCR degradation.K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signalingLAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ.NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease.Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.Inducible turnover of optineurin regulates T cell activation.
P2860
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P2860
Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Src-like adaptor protein down- ...... eting TCRzeta for degradation.
@en
type
label
Src-like adaptor protein down- ...... eting TCRzeta for degradation.
@en
prefLabel
Src-like adaptor protein down- ...... eting TCRzeta for degradation.
@en
P2860
P356
P1476
Src-like adaptor protein down- ...... eting TCRzeta for degradation.
@en
P2093
Leonard L Dragone
Margaret D Myers
P2860
P304
P356
10.1083/JCB.200501164
P407
P50
P577
2005-07-01T00:00:00Z