Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells.
about
Selection of the best target site for ribozyme-mediated cleavage within a fusion gene for adenovirus E1A-associated 300 kDa protein (p300) and luciferase.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsDevelopment of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics.Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes.The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes.A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets.Hammerhead ribozyme kinetics.
P2860
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P2860
Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Extension of helix II of an HI ...... ory potential in living cells.
@en
type
label
Extension of helix II of an HI ...... ory potential in living cells.
@en
prefLabel
Extension of helix II of an HI ...... ory potential in living cells.
@en
P2093
P2860
P356
P1476
Extension of helix II of an HI ...... ory potential in living cells.
@en
P2093
Sczakiel G
Tzortzakaki S
P2860
P304
P356
10.1093/NAR/22.19.3951
P577
1994-09-01T00:00:00Z