Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. - Wikidata - wikimedia - TriplyDB

Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

http://www.wikidata.org/entity/Q40420617

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Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90 Cyclin-dependent kinase inhibitor therapy for hematologic malignancies mir-29 regulates Mcl-1 protein expression and apoptosis Apoptotic pathways as a therapeutic target for colorectal cancer treatment The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations Altering chemosensitivity by modulating translation elongation A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands Mitochondrial apoptosis and BH3 mimetics Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.Mcl-1 is essential for the survival of plasma cells.Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.An atlas of altered expression of deubiquitinating enzymes in human cancer A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.Gene expression of anti- and pro-apoptotic proteins in malignant and normal plasma cells.Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects.Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth.Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect.Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1.Apoptotic and autophagic effects of Sesbania grandiflora flowers in human leukemic cells.RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2.MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.Monitoring a nuclear factor-κB signature of drug resistance in multiple myeloma.SNS01-T modulation of eIF5A inhibits B-cell cancer progression and synergizes with bortezomib and lenalidomide.Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis.

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Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

http://www.wikidata.org/entity/Q40420617

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Mcl-1 is overexpressed in mult ...... relapse and shorter survival.

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Mcl-1 is overexpressed in mult ...... relapse and shorter survival.

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Mcl-1 is overexpressed in mult ...... relapse and shorter survival.

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Mcl-1 is overexpressed in mult ...... h relapse and shorter survival

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P2093

Amiot M

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Bataille R

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Gomez P

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Harousseau JL

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Le Gouill S

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Moreau P

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Robillard N

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Wuillème-Toumi S

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P2860

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells.

Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.

Myeloid cell factor-1 is a critical survival factor for multiple myeloma.

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32).

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein.

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms.

Identification of genes modulated in multiple myeloma using genetically identical twin samples.

Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia.

MCL-1 promoter insertions dial-up aggressiveness of chronic leukemia.

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1248-1252

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scholarly article

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10.1038/SJ.LEU.2403784

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7

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19

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Herve Avet-Loiseau

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2005-07-01T00:00:00Z

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7839879

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1024185256

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15902294

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