PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. - Wikidata - wikimedia - TriplyDB

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

http://www.wikidata.org/entity/Q42811887

about

BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation.The role of the PTEN/PI3K/Akt pathway on prognosis in epithelial ovarian cancer: a meta-analysis High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)Mechanisms by which IGF-I may promote cancer SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer A framework for genomic biomarker actionability and its use in clinical decision making Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.Caspase-mediated cell death in hematological malignancies: theoretical considerations, methods of assessment, and clinical implications.Defining the role of TORC1/2 in multiple myeloma.The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells.Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.Six1 induces protein synthesis signaling expression in duck myoblasts mainly via up-regulation of mTOR Type I insulin-like growth factor receptor signaling in hematological malignancies.Inhibitor and activator: dual functions for SHIP in immunity and cancer.From cell biology to therapy: ENMD-2076 in the treatment of multiple myeloma.Targeting the bone marrow in Waldenstrom macroglobulinemia.Do annexins participate in lipid messenger mediated intracellular signaling? A question revisited.AKT as a therapeutic target in multiple myeloma.Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies.Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease.Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib.Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype.Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses.Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas.Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.Microenvironment factors do not afford myeloma cell lines protection from simvastatin.Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells.Inhibition of transfected PTEN on human colon cancer.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.Phase IB study of cabozantinib in patients with relapsed and/or refractory multiple myeloma.PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line.Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease.SHIP negatively regulates type II immune responses in mast cells and macrophages.Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death.

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P2860

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

http://www.wikidata.org/entity/Q42811887

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

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name

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@en

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@nl

type

label

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@en

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@nl

prefLabel

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@en

PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

@nl

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PTEN, but not SHIP and SHIP2, ...... nd apoptosis of myeloma cells.

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Brett P Monia

http://www.w3.org/2001/XMLSchema#string

Cristina Murga

http://www.w3.org/2001/XMLSchema#string

Erich Koller

http://www.w3.org/2001/XMLSchema#string

Hong Yu

http://www.w3.org/2001/XMLSchema#string

J Silvio Gutkind

http://www.w3.org/2001/XMLSchema#string

Jie Zhang

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Weiqun Li

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Yong Choi

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P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Phosphorylation and activation of p70s6k by PDK1

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

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5289-5300

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10.1038/SJ.ONC.1205650

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34

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21

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