Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.
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pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epitheliaPromoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayRapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cellsE2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loopIncreased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virusDifferential role of RB in response to UV and IR damage.Report on the use of non-clinical studies in the regulatory evaluation of oncology drugsN-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiationMultiple recurrent genetic events converge on control of histone lysine methylation in medulloblastomaCerebellum development and medulloblastomaDevelopment and cancer of the cerebellumInactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.EGF receptor is required for KRAS-induced pancreatic tumorigenesisRepression by RB1 characterizes genes involved in the penultimate stage of erythroid developmentGFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumorsSTAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.Lineage of origin in rhabdomyosarcoma informs pharmacological responseRetinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells.Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunctionConditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.In vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal miceNon-cell-autonomous tumor suppression by p53.Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells.Compensation by tumor suppressor genes during retinal development in mice and humans.Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.Retinoblastoma loss modulates DNA damage response favoring tumor progressionTimed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.Biology of urothelial tumorigenesis: insights from genetically engineered mice.The retinoblastoma tumor-suppressor gene, the exception that proves the ruleAberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.Transgenic mouse models for studying adult neurogenesis.Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) geneResearch findings working with the p53 and Rb1 targeted osteosarcoma mouse model.
P2860
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P2860
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Induction of medulloblastomas ...... layer cells of the cerebellum.
@en
type
label
Induction of medulloblastomas ...... layer cells of the cerebellum.
@en
prefLabel
Induction of medulloblastomas ...... layer cells of the cerebellum.
@en
P2093
P2860
P1433
P1476
Induction of medulloblastomas ...... layer cells of the cerebellum.
@en
P2093
P2860
P304
P577
2000-04-01T00:00:00Z