Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
about
The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cellsProtein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestorStructure of a lipid-bound extended synaptotagmin indicates a role in lipid transferA Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase geneMultiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activationIdentification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptorOrphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17Structural and functional characterization of a novel type of ligand-independent RXR-USP receptorCyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylationIdentification of a physiologically relevant endogenous ligand for PPARalpha in liverFive novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiencyGPR30: A G protein-coupled receptor for estrogenAtrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humansEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast CancerNuclear Receptors, RXR, and the Big BangPhospholipid--driven gene regulationDifferentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cellsPhosphoinositides: tiny lipids with giant impact on cell regulationDefects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stressesUnexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expressionStructure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory LigandsThe structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear ReceptorsStructural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in NematodesStructural basis of coactivation of liver receptor homolog-1 by -cateninDivergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone ReceptorsAntidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulationMedium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial AgonistsStructural insights into gene repression by the orphan nuclear receptor SHPVestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone ReceptorCrystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of ActivationSilencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cellscAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and functionTIPE3 is the transfer protein of lipid second messengers that promote cancer
P2860
Q21144313-474B8148-1145-4D54-86DC-92AAB9CB933FQ21145789-D1C18B8E-4D0E-492E-9838-0AD953DA171EQ24298007-FF2124DE-71E8-4FC1-AA71-F49C43B4A6DFQ24305147-0D245B1C-5F74-4825-B32D-659A255B9F5EQ24309467-E7767159-A505-478A-8BC1-BB8BDBC29A1EQ24313503-628F6BBA-FE76-4E6D-8C29-0E1A1EA7331AQ24314492-2C8AEDF3-38D4-4F4E-B7D7-01035E6A0ACDQ24323350-37A6426E-B874-4FFC-9BE0-7D17E38E6A0EQ24336232-6043CB3A-BE27-489B-A044-27B6E7CCAC55Q24338920-1177D6C4-FC58-41B9-953A-EB39B665C287Q24653691-C3E62321-ED40-452B-A542-39375F21301EQ24654062-C7068C99-3A99-40F3-B6E4-F2B6EF23C2ECQ24670959-64ACA3C1-4C3A-422C-9661-21BE87BAF885Q24685808-28BF7349-D382-4087-9BBC-F84E21AB5A15Q24815571-6C002606-0E91-4683-B0EE-59BE8621A1B8Q26795488-3F7F310E-DA33-41CC-9163-E0F06CDE2EE3Q26821789-1ECA934D-E733-4654-83D6-D89BDF59D832Q26822791-E2C726A4-44CC-4A8D-A992-E7B5B8890895Q27003727-41CE6969-66B8-41F1-9283-C2F2A1EDF837Q27012953-93D11B86-E3AC-4E19-B403-8BDDA655A922Q27313906-902D0128-9C34-436F-BFB6-8B0DF3B7DD65Q27314765-68B4A900-715A-4CB1-9686-B60B9F90C0A8Q27652795-743123BE-FD20-49B6-B96C-B6DAA9559FE4Q27652923-6323E08C-FFDF-4568-8409-5ED43A28E9D9Q27667247-8B976C21-FAD6-48A0-BCD0-F152C50FFA66Q27670905-B31B1E4A-C266-4E43-A503-3F30C120E876Q27676200-C0E4EE80-2B8F-49CB-B43C-0D7F1873F36FQ27676342-10A08D1C-FB5B-4E48-8F16-718855BE9A02Q27678497-F41F8CC6-AFE2-4D1F-80E4-B09F07B96CF9Q27678520-278E9CB5-4693-4406-B4DC-330628B77FCBQ27679376-4B1E224E-7994-497C-813F-F90D8CAF496BQ27681139-BD499707-2827-4D26-B8DD-5BFE302301B9Q27681285-FB6DCC11-96B9-4927-B988-0462AFC63351Q27728159-B09E12FD-0AF1-4F6F-89BA-384FAB303FE9Q28115074-738F4401-E81B-4785-ABBD-904AFE2F80F0Q28115537-08AFBAD9-C6D5-4835-B537-CC0CF5721ED3Q28553211-84B242F3-AD66-4B51-A72D-FDFC17137B71Q28584186-48CAD102-6FB2-45B6-8152-44DA66123747Q28585500-5034EEE7-B549-4062-B9D7-720EDDABC7DDQ28587461-5D4B6670-96AA-45F8-B79F-74B93E9FAC1E
P2860
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Structural analyses reveal pho ...... phan receptors SF-1 and LRH-1.
@en
type
label
Structural analyses reveal pho ...... phan receptors SF-1 and LRH-1.
@en
prefLabel
Structural analyses reveal pho ...... phan receptors SF-1 and LRH-1.
@en
P2093
P1433
P1476
Structural analyses reveal pho ...... phan receptors SF-1 and LRH-1.
@en
P2093
Dalia Juzumiene
Elena P Sablin
Gregory M Waitt
Holly A Ingraham
Irina N Krylova
J Andrew MacKay
Jamie Moore
Jane M Bynum
Jon D Williams
Joseph W Thornton
P304
P356
10.1016/J.CELL.2005.01.024
P407
P577
2005-02-01T00:00:00Z