Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells. - Wikidata - wikimedia - TriplyDB

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

http://www.wikidata.org/entity/Q40470308

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Near IR heptamethine cyanine dye-mediated cancer imaging Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line Targeting the Mitotic Catastrophe Signaling Pathway in Cancer Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube.Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer.Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor Mechanical aspects of microtubule bundling in taxane-treated circulating tumor cells A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model.A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study.Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies.Eg5 inhibitor, a novel potent targeted therapy, induces cell apoptosis in renal cell carcinoma.Killing cells by targeting mitosis Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis A Potent Chemotherapeutic Strategy with Eg5 Inhibitor against Gemcitabine Resistant Bladder Cancer.The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells.Development of new cancer therapeutic agents targeting mitosis.Actin- and microtubule-targeting bioprobes: their binding sites and inhibitory mechanisms.Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin.Mitosis as an anti-cancer target.Mitosis-targeted anti-cancer therapies: where they stand.Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy.Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor.Synthesis and evaluation of biphenyl compounds as kinesin spindle protein inhibitors.Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol.A good molecular target for prostate cancer chemotherapy.Kinesin 18A expression: clinical relevance to colorectal cancer progression.S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor.Autophagy-Dependent Survival of Mutant B-Raf Melanoma Cells Selected for Resistance to Apoptosis Induced by Inhibitors against Oncogenic B-Raf Identification of the binding site of an allosteric ligand using STD-NMR, docking, and CORCEMA-ST calculations High Eg5 expression predicts poor prognosis in breast cancer.

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P2860

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

http://www.wikidata.org/entity/Q40470308

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Mitotic kinesin inhibitors ind ...... t and -sensitive cancer cells.

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Mitotic kinesin inhibitors ind ...... nt and -sensitive cancer cells

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Adam I Marcus

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Amelia Zelnak

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Paraskevi Giannakakou

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Sarah Garrett

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Shala L Thomas

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Tarun M Kapoor

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P2860

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

Multidrug resistance in cancer: role of ATP-dependent transporters

Microtubules as a target for anticancer drugs

THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

New colorimetric cytotoxicity assay for anticancer-drug screening

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics.

Mechanisms of Taxol resistance related to microtubules.

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1861807

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