Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
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Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosisCell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activitiesA model for the mechanism of strand passage by DNA gyraseCharacterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsNitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor CellsImportance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.Casein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody.Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.Evaluation of topotecan and etoposide for non-Hodgkin lymphoma: correlation of topoisomerase-DNA complex formation with clinical response.Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathwayPharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancerDual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cellsNewly identified antibacterial compounds are topoisomerase poisons in African trypanosomesSensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsA diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymesTransgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans.Assessing sensitivity to antibacterial topoisomerase II inhibitors.Selection of genetic suppressor elements conferring resistance to DNA topoisomerase II inhibitors.Why eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity.Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action.Antifungal activity of eupolauridine and its action on DNA topoisomerasesA gyrase mutant with low activity disrupts supercoiling at the replication terminusMechanisms regulating resistance to inhibitors of topoisomerase II.Caspases target only two architectural components within the core structure of the nuclear pore complex.Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitorTopoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells.Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulans.Processing of topoisomerase I cleavable complexes into DNA damage by transcription.Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes.Identification of new p53 target microRNAs by bioinformatics and functional analysisSelective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazolesHaplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination
P2860
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P2860
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
@en
type
label
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
@en
prefLabel
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
@en
P356
P1476
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.
@en
P2093
N Osheroff
S J Froelich-Ammon
P304
21429-21432
P356
10.1074/JBC.270.37.21429
P407
P577
1995-09-01T00:00:00Z