Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
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Five dysfunctional telomeres predict onset of senescence in human cellsThe human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activityWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesA quantitative telomeric chromatin isolation protocol identifies different telomeric statesHuman POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinIsolation of human Dna2 endonuclease and characterization of its enzymatic propertiesPurification of proteins associated with specific genomic LociHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationThe spectrum of WRN mutations in Werner syndrome patientsPhysical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsThe RecQ DNA helicases in DNA repairShelterin complex and associated factors at human telomeresTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyRoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesIn vivo veritas: using yeast to probe the biological functions of G-quadruplexesHuman RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication forkHuman premature aging, DNA repair and RecQ helicasesEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Structure and function of the telomeric CST complexTelomeres and telomerase as therapeutic targets to prevent and treat age-related diseasesG-quadruplexes and helicasesG-quadruplexes and their regulatory roles in biologyReplication of Structured DNA and its implication in epigenetic stabilityTelomere shortening in human diseasesMetabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceSenescence and the pro-tumorigenic stromaRecQ helicases in DNA double strand break repair and telomere maintenance.The THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningSurvival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9.Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.Evidence that a RecQ helicase slows senescence by resolving recombining telomeresPhysiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear EdgeMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityKu86 represses lethal telomere deletion events in human somatic cellsWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsQuantitative visualization of DNA G-quadruplex structures in human cells
P2860
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P2860
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
@en
type
label
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
@en
prefLabel
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
@en
P2093
P356
P1433
P1476
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
@en
P2093
Candy I Haggblom
Jan Karlseder
Laure Crabbe
Ramiro E Verdun
P304
P356
10.1126/SCIENCE.1103619
P407
P577
2004-12-01T00:00:00Z