WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening
about
Shelterin complex and associated factors at human telomeresRoles of Werner syndrome protein in protection of genome integrityExtrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cellsKu86 represses lethal telomere deletion events in human somatic cellsThe Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationWRN loss induces switching of telomerase-independent mechanisms of telomere elongationThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsMechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseReplication protein A stimulates the Werner syndrome protein branch migration activity.Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activityProcessing of human telomeres by the Werner syndrome protein.Telomeric circles: universal players in telomere maintenance?Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome proteinThe pur protein family: genetic and structural features in development and disease.Telomere reprogramming and maintenance in porcine iPS cells.Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells.RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Human RecQ helicases in DNA repair, recombination, and replication.Stem cell aging in adult progeria.Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Chromatin structure in telomere dynamics5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events.BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivoTRF2 promotes, remodels and protects telomeric Holliday junctions.Telomeres do the (un)twist: helicase actions at chromosome termini.Human TEN1 maintains telomere integrity and functions in genome-wide replication restartKu's essential role in keeping telomeres intactThe Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.Telomeric armor: the layers of end protection.The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.Structural identity of telomeric complexes.The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA.Ku circles the telomere?Cell cycle-regulated association between the Werner syndrome protein and its molecular partners.
P2860
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P2860
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
WRN controls formation of extr ...... B-mediated telomere shortening
@ast
WRN controls formation of extr ...... B-mediated telomere shortening
@en
WRN controls formation of extr ...... B-mediated telomere shortening
@en-gb
WRN controls formation of extr ...... B-mediated telomere shortening
@nl
type
label
WRN controls formation of extr ...... B-mediated telomere shortening
@ast
WRN controls formation of extr ...... B-mediated telomere shortening
@en
WRN controls formation of extr ...... B-mediated telomere shortening
@en-gb
WRN controls formation of extr ...... B-mediated telomere shortening
@nl
prefLabel
WRN controls formation of extr ...... B-mediated telomere shortening
@ast
WRN controls formation of extr ...... B-mediated telomere shortening
@en
WRN controls formation of extr ...... B-mediated telomere shortening
@en-gb
WRN controls formation of extr ...... B-mediated telomere shortening
@nl
P2093
P2860
P921
P356
P1476
WRN controls formation of extr ...... B-mediated telomere shortening
@en
P2093
Lucio Comai
Sita Reddy
Sonali P Jog
P2860
P304
P356
10.1128/MCB.01364-07
P407
P577
2008-03-01T00:00:00Z