Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.
about
The pseudo GTPase CENP-M drives human kinetochore assemblyLoss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisMammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.Formins and microtubulesThe role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applicationsHow microRNAs influence both hereditary and inflammatory-mediated colon cancersInhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathwayUncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrestAPC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and humanSustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer AssayA conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesisDetecting statistical interaction between somatic mutational events and germline variation from next-generation sequence data.GSK-3 inhibitors induce chromosome instability.Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.p53 suppresses structural chromosome instability after mitotic arrest in human cells.Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cellsDeficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histologyPro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Spindle microtubule dysfunction and cancer predispositionThe adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatinComprehensive mutation analysis in colorectal flat adenomasBimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signalingCohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestTissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signalingUnderstanding cytokinesis failure.Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cellsCortical localization of APC2 plays a role in actin organization but not in Wnt signaling in DrosophilaSubcellular spatial regulation of canonical Wnt signalling at the primary ciliumMicroRNA-mediated repression of nonsense mRNAs.p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit.Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochoresA conserved function for the H2A.Z C terminus.Losing balance: the origin and impact of aneuploidy in cancerOutlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine.
P2860
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P2860
Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Truncating APC mutations have ...... ival and chromosome stability.
@en
type
label
Truncating APC mutations have ...... ival and chromosome stability.
@en
prefLabel
Truncating APC mutations have ...... ival and chromosome stability.
@en
P356
P1476
Truncating APC mutations have ...... vival and chromosome stability
@en
P2093
Anthony Tighe
Victoria L Johnson
P304
P356
10.1242/JCS.01556
P407
P577
2004-11-23T00:00:00Z