Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.
about
Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound stateSplenomegaly and modified erythropoiesis in KLF13-/- miceAdvances in understanding the pathogenesis of primary familial and congenital polycythaemiaErythropoietin receptor signaling is membrane raft dependent.Lyn kinase promotes erythroblast expansion and late-stage development.Functions of the Lyn tyrosine kinase in health and diseaseCross-regulation of JAK and Src kinases.The signaling mechanism of eosinophil activation.Integrating novel signaling pathways involved in erythropoiesis.Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival.Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway.Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.Activation of STAT3 stimulates AHSP expression in K562 cells.Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria.
P2860
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P2860
Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Lyn deficiency reduces GATA-1, ...... dullary stress erythropoiesis.
@en
type
label
Lyn deficiency reduces GATA-1, ...... dullary stress erythropoiesis.
@en
prefLabel
Lyn deficiency reduces GATA-1, ...... dullary stress erythropoiesis.
@en
P2093
P2860
P356
P1433
P1476
Lyn deficiency reduces GATA-1, ...... edullary stress erythropoiesis
@en
P2093
Aini S Adenan
David J McCarthy
Jessica R Pore
Michael J Wright
Peta A Tilbrook
S Peter Klinken
Wendy Erber
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208199
P407
P577
2005-01-01T00:00:00Z
P5875
P6179
1019741088