The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. - Wikidata - wikimedia - TriplyDB

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

http://www.wikidata.org/entity/Q40506613

about

The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6 Regulated association of protein kinase B/Akt with breast tumor kinase Phosphorylation-mediated regulation of alternative splicing in cancer PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1 Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin.Brk/PTK6 signaling in normal and cancer cell models.Control of messenger RNA fate by RNA-binding proteins: an emphasis on mammalian spermatogenesis Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116 Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6 PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo Establishment of a novel in vivo sex-specific splicing assay system to identify a trans-acting factor that negatively regulates splicing of Bombyx mori dsx female exons PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.Role of RNA-binding proteins in mammalian spermatogenesis.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2 Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients.Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.

P2860

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P2860

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

http://www.wikidata.org/entity/Q40506613

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

The nuclear tyrosine kinase BR ...... lian proteins SLM-1 and SLM-2.

@en

type

label

The nuclear tyrosine kinase BR ...... lian proteins SLM-1 and SLM-2.

@en

prefLabel

The nuclear tyrosine kinase BR ...... lian proteins SLM-1 and SLM-2.

@en

P1433

Q40506613-C195548E-03E5-4023-AA85-D411301435A8

P1476

Q40506613-A274D8C3-D62D-4572-B74E-98F017C517E8

P2093

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P2860

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P304

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P31

Q40506613-6AF0FD60-E41D-4AFA-B600-206CB4EF4E32

P356

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P478

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P921

Q40506613-7F912BA0-EBF9-421C-A4AC-AA157A25FD7F

P356

P1433

Journal of Biological Chemistry

P1476

The nuclear tyrosine kinase BR ...... lian proteins SLM-1 and SLM-2.

@en

P2093

Andrea Haegebarth

http://www.w3.org/2001/XMLSchema#string

Darien Heap

http://www.w3.org/2001/XMLSchema#string

Jason J Derry

http://www.w3.org/2001/XMLSchema#string

Stéphane Richard

http://www.w3.org/2001/XMLSchema#string

Wenjun Bie

http://www.w3.org/2001/XMLSchema#string

P2860

T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1

Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors

Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

P304

54398-54404

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P31

scholarly article

P356

10.1074/JBC.M409579200

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P407

P433

52

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P478

279

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P50

Angela L. Tyner

P577

2004-10-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15471878

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation