Markov propagation of allosteric effects in biomolecular systems: application to GroEL-GroES.
about
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewChanges in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members"Fluctuograms" reveal the intermittent intra-protein communication in subtilisin Carlsberg and correlate mechanical coupling with co-evolutionConformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulationsPerturbation-based Markovian transmission model for probing allosteric dynamics of large macromolecular assembling: a study of GroEL-GroESSolution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methodsSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsQuantifying Correlations Between Allosteric Sites in Thermodynamic EnsemblesBinding leverage as a molecular basis for allosteric regulationTowards structural systems pharmacology to study complex diseases and personalized medicineMutations in Antibody Fragments Modulate Allosteric Response Via Hydrogen-Bond Network Fluctuations.Modeling allosteric signal propagation using protein structure networksCoherent conformational degrees of freedom as a structural basis for allosteric communication.MCPath: Monte Carlo path generation approach to predict likely allosteric pathways and functional residues.Dynamics of allosteric transitions in GroEL.Dynamic allostery in the methionine repressor revealed by force distribution analysis.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesRecruitment of rare 3-grams at functional sites: is this a mechanism for increasing enzyme specificity?Signal propagation in proteins and relation to equilibrium fluctuationsSrc kinase conformational activation: thermodynamics, pathways, and mechanisms.Allosteric transitions of supramolecular systems explored by network models: application to chaperonin GroEL.Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic modelStructure-based predictive models for allosteric hot spots.On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm.Optimal identification of semi-rigid domains in macromolecules from molecular dynamics simulation.Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.Allosteric switching of agonist/antagonist activity by a single point mutation in the interluekin-1 receptor antagonist, IL-1RaLigand-induced protein responses and mechanical signal propagation described by linear response theoriesAllosteric communication across the native and mutated KIT receptor tyrosine kinase.Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species ConservationA mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein.Dynamical networks in tRNA:protein complexes.QAARM: quasi-anharmonic autoregressive model reveals molecular recognition pathways in ubiquitinDifferential effects of CSF-1R D802V and KIT D816V homologous mutations on receptor tertiary structure and allosteric communicationATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.Communication routes in ARID domains between distal residues in helix 5 and the DNA-binding loops.Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein.Allosteric transitions in the chaperonin GroEL are captured by a dominant normal mode that is most robust to sequence variations.Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication Pathways
P2860
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P2860
Markov propagation of allosteric effects in biomolecular systems: application to GroEL-GroES.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Markov propagation of alloster ...... s: application to GroEL-GroES.
@en
type
label
Markov propagation of alloster ...... s: application to GroEL-GroES.
@en
prefLabel
Markov propagation of alloster ...... s: application to GroEL-GroES.
@en
P2860
P356
P1476
Markov propagation of alloster ...... s: application to GroEL-GroES.
@en
P2093
Chakra Chennubhotla
P2860
P356
10.1038/MSB4100075
P50
P577
2006-07-04T00:00:00Z