Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
about
Many local motions cooperate to produce the adenylate kinase conformational transitionEverything you wanted to know about Markov State Models but were afraid to askSRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspectiveExploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loopHierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectoriesA comparative analysis of clustering algorithms: O2 migration in truncated hemoglobin I from transition networks.Ligand-induced global transitions in the catalytic domain of protein kinase A.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesSequence and structure signatures of cancer mutation hotspots in protein kinasesComputational insights for the discovery of non-ATP competitive inhibitors of MAP kinasesp66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.Large conformational changes in proteins: signaling and other functions.Protein dynamics investigated by inherent structure analysis.Predicting inactive conformations of protein kinases using active structures: conformational selection of type-II inhibitors.Network models for molecular kinetics and their initial applications to human healthMultidomain assembled states of Hck tyrosine kinase in solution.Exploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.Quantitative analysis of ligand migration from transition networksAutomatic Selection of Order Parameters in the Analysis of Large Scale Molecular Dynamics Simulations.X-ray solution scattering studies of the structural diversity intrinsic to protein ensemblesComputational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases.Simulations of the alternating access mechanism of the sodium symporter Mhp1.Activation pathway of Src kinase reveals intermediate states as targets for drug designαC helix as a switch in the conformational transition of Src/CDK-like kinase domains.Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src KinaseMultiple steps to activate FAK's kinase domain: adaptation to confined environments?Biomolecular dynamics: order-disorder transitions and energy landscapesA rapid coarse residue-based computational method for x-ray solution scattering characterization of protein folds and multiple conformational states of large protein complexes.Computational study of the W260A activating mutant of Src tyrosine kinase.Unrestrained computation of free energy along a path.Coarse-grained simulations of protein-protein association: an energy landscape perspective.Network visualization of conformational sampling during molecular dynamics simulation.Atomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories.Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.Minimum action transition paths connecting minima on an energy surface.
P2860
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P2860
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@ast
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@en
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@nl
type
label
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@ast
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@en
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@nl
prefLabel
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@ast
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@en
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@nl
P2860
P1476
Src kinase conformational activation: thermodynamics, pathways, and mechanisms.
@en
P2093
Benoît Roux
P2860
P304
P356
10.1371/JOURNAL.PCBI.1000047
P50
P577
2008-03-28T00:00:00Z