Hsp90 chaperones wild-type p53 tumor suppressor protein.
about
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylaseThe diverse members of the mammalian HSP70 machine show distinct chaperone-like activitiesCooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machineryProteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cellsThe architecture of functional modules in the Hsp90 co-chaperone Sti1/HopThe hsp90 molecular chaperone modulates multiple telomerase activities.Hsp90 is regulated by a switch point in the C-terminal domainSilica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell LineThe mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.p53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.Promoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumorsProteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.p53 protects against LPS-induced lung endothelial barrier dysfunction.A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of PluripotencyCombined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.Bacillus subtilis glutamine synthetase regulates its own synthesis by acting as a chaperone to stabilize GlnR-DNA complexes.p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.Reactivation of mutant p53: molecular mechanisms and therapeutic potential.Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression.Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivativesA mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinaseInhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.HSP90 manages the ends.Tp53 and its potential therapeutic role as a target in bladder cancer.HSP90AB1: Helping the good and the bad.Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.DNA-binding regulates site-specific ubiquitination of IRF-1.ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein.The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin.α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation.Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells.MDM2 chaperones the p53 tumor suppressor.
P2860
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P2860
Hsp90 chaperones wild-type p53 tumor suppressor protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Hsp90 chaperones wild-type p53 tumor suppressor protein.
@en
type
label
Hsp90 chaperones wild-type p53 tumor suppressor protein.
@en
prefLabel
Hsp90 chaperones wild-type p53 tumor suppressor protein.
@en
P2093
P2860
P50
P356
P1476
Hsp90 chaperones wild-type p53 tumor suppressor protein.
@en
P2093
Aleksandra Helwak
Alicja Zylicz
Frank W King
Joanna Boros
Lin Muller
Malgorzata Gutkowska
P2860
P304
48836-48845
P356
10.1074/JBC.M407601200
P407
P577
2004-09-09T00:00:00Z