Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.
about
Biomarkers and molecular probes for cell death imaging and targeted therapeuticsPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesBid-induced release of AIF from mitochondria causes immediate neuronal cell deathNMR-based analysis of protein-ligand interactions.Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.Bid regulates the pathogenesis of neurotropic reovirus.Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cellsEfficient synthetic inhibitors of anthrax lethal factor.Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cellsPerspectives on NMR in drug discovery: a technique comes of ageDifferential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressantsNMR-based techniques in the hit identification and optimisation processes.Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells.The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.Targeting tumor invasion: the roles of MDA-9/Syntenin.Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities.Regulation and pathological role of bid in ischemic acute kidney injury.Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke.Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2).Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.N-acyl derivatives of 4-phenoxyaniline as neuroprotective agents.Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent.Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitorsBid binding to negatively charged phospholipids may not be required for its pro-apoptotic activity in vivoInhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.Pharmacological manipulation of Bcl-2 family members to control cell death.Death pathways associated with photodynamic therapy.Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategiesDevelopment of paramagnetic probes for molecular recognition studies in protein kinases.Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid.Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line.A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
P2860
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P2860
Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Targeting apoptosis via chemic ...... th by small organic molecules.
@en
type
label
Targeting apoptosis via chemic ...... th by small organic molecules.
@en
prefLabel
Targeting apoptosis via chemic ...... th by small organic molecules.
@en
P2093
P1476
Targeting apoptosis via chemic ...... ath by small organic molecules
@en
P2093
Dayong Zhai
John C Reed
Kevin J Crowell
Maurizio Pellecchia
Sina Sareth
P304
P356
10.1016/J.CHEMBIOL.2004.05.022
P577
2004-08-01T00:00:00Z