Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. - Wikidata - wikimedia - TriplyDB

Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.

Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.

http://www.wikidata.org/entity/Q40533705

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Molecular details of cAMP generation in mammalian cells: a tale of two systems Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases Mitochondria and cardiovascular aging Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Structure-based development of novel adenylyl cyclase inhibitors Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses Gβγ subunits inhibit Epac-induced melanoma cell migration.Gene expression and β-adrenergic signaling are altered in hypoplastic left heart syndrome.beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.Differential roles of Epac in regulating cell death in neuronal and myocardial cells.Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection Inhibitors of membranous adenylyl cyclases.cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.Creating order from chaos: cellular regulation by kinase anchoring.Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.A Food and Drug Administration-Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion.Pharmacological distinction between soluble and transmembrane adenylyl cyclases.Epac increases melanoma cell migration by a heparan sulfate-related mechanism.cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.Rapid and pervasive changes in genome-wide enhancer usage during mammalian development.Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms.Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling.International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Epac1 promotes melanoma metastasis via modification of heparan sulfate.Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal.

P2860

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P2860

Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.

http://www.wikidata.org/entity/Q40533705

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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Direct inhibition of type 5 ad ...... hout functional deterioration.

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Direct inhibition of type 5 ad ...... hout functional deterioration.

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Direct inhibition of type 5 ad ...... hout functional deterioration.

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Journal of Biological Chemistry

P1476

Direct inhibition of type 5 ad ...... hout functional deterioration.

@en

P2093

Daniel E Levy

http://www.w3.org/2001/XMLSchema#string

James E Tomlinson

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Kousaku Iwatsubo

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Masamichi Nakagome

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Robert M Scarborough

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Satoshi Umemura

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Susumu Minamisawa

http://www.w3.org/2001/XMLSchema#string

Takashi Tsunematsu

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Yoshihiro Ishikawa

http://www.w3.org/2001/XMLSchema#string

Yoshiyuki Toya

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P2860

Molecular basis for P-site inhibition of adenylyl cyclase

Regulation of adenylyl cyclase by protein kinase A

Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling.

Regulation and role of adenylyl cyclase isoforms.

Compartmentation of G protein-coupled signaling pathways in cardiac myocytes.

Beta-adrenergic blocking drugs in the treatment of hypertension.

Two distinct adenosine-sensitive sites on adenylate cyclase.

Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy.

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40938-40945

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10.1074/JBC.M314238200

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P433

39

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P478

279

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2004-07-15T00:00:00Z

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15262973

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