Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.
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Molecular details of cAMP generation in mammalian cells: a tale of two systemsRegulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factorThe cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory DiseasesMitochondria and cardiovascular agingSimilarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout miceStore-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migrationAdenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscleNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Structure-based development of novel adenylyl cyclase inhibitorsEpac1-dependent phospholamban phosphorylation mediates the cardiac response to stressesGβγ subunits inhibit Epac-induced melanoma cell migration.Gene expression and β-adrenergic signaling are altered in hypoplastic left heart syndrome.beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.Differential roles of Epac in regulating cell death in neuronal and myocardial cells.Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.cAMP level modulates scleral collagen remodeling, a critical step in the development of myopiaIsoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compoundsDevelopment of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytesA kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protectionInhibitors of membranous adenylyl cyclases.cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of EpacPrevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclaseThe A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.Creating order from chaos: cellular regulation by kinase anchoring.Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.A Food and Drug Administration-Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion.Pharmacological distinction between soluble and transmembrane adenylyl cyclases.Epac increases melanoma cell migration by a heparan sulfate-related mechanism.cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.Rapid and pervasive changes in genome-wide enhancer usage during mammalian development.Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms.Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling.International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Epac1 promotes melanoma metastasis via modification of heparan sulfate.Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphatesDopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal.
P2860
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P2860
Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Direct inhibition of type 5 ad ...... hout functional deterioration.
@en
type
label
Direct inhibition of type 5 ad ...... hout functional deterioration.
@en
prefLabel
Direct inhibition of type 5 ad ...... hout functional deterioration.
@en
P2093
P2860
P356
P1476
Direct inhibition of type 5 ad ...... hout functional deterioration.
@en
P2093
Daniel E Levy
James E Tomlinson
Kousaku Iwatsubo
Masamichi Nakagome
Robert M Scarborough
Satoshi Umemura
Susumu Minamisawa
Takashi Tsunematsu
Yoshihiro Ishikawa
Yoshiyuki Toya
P2860
P304
40938-40945
P356
10.1074/JBC.M314238200
P407
P577
2004-07-15T00:00:00Z