The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. - Wikidata - wikimedia - TriplyDB

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

http://www.wikidata.org/entity/Q40541045

about

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma Ligand-Independent EGFR Signaling The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody.Mig-6 controls EGFR trafficking and suppresses gliomagenesis The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2 Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII.Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma.The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer.Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo Activated epidermal growth factor receptor in ovarian cancer.Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation.The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases.Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo.An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy.Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates.SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.Ligand binding induces a conformational change in epidermal growth factor receptor dimers.Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer.EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism.Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme.Analysis of Interactions between the Epidermal Growth Factor Receptor and Soluble Ligands on the Basis of Single-Molecule Diffusivity in the Membrane of Living Cells.Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation.Synthetic cytokine receptors transmit biological signals using artificial ligands.

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The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.

http://www.wikidata.org/entity/Q40541045

description

2004 nî lūn-bûn

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2004年の論文

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The tumor-specific de2-7 epide ...... rizes with the wild-type EGFR.

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The tumor-specific de2-7 epide ...... rizes with the wild-type EGFR.

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The tumor-specific de2-7 epide ...... rizes with the wild-type EGFR.

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The tumor-specific de2-7 epide ...... rizes with the wild-type EGFR.

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P2093

Andrew M Scott

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Angela A Vitali

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Antony W Burgess

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Francesca Walker

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Hong-Jian Zhu

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Rushika M Perera

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P2860

Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival.

The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

Cellular survival: a play in three Akts

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.

EGF mutant receptor vIII as a molecular target in cancer therapy.

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy.

Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts

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10.1038/SJ.ONC.1207870

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36

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23

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Terrance G Johns

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