Tissue-specific mutation accumulation in human adult stem cells during life.
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Accumulation of DNA damage in the aged hematopoietic stem cell compartmentThe Origins of Gastric Cancer From Gastric Stem Cells: LessonsĀ From Mouse Models.Differences between germline and somatic mutation rates in humans and mice.Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue.An alternative model for (breast) cancer predisposition.Tissue-specific tumorigenesis: context matters.Emerging concepts in liquid biopsiesWhen Should Genetic Testing Be Performed in Epilepsy Patients?Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinomaGenomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.Contrasting Determinants of Mutation Rates in Germline and Soma.Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing.Molecular Analysis of Genetic Markers for Non-Hodgkin Lymphomas.Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.Modelling Mutation Spectra of Human Carcinogens Using Experimental Systems.Alternative roles for oxidized mCs and TETs.A population genetics perspective on the determinants of intra-tumor heterogeneity.Modeling the process of human tumorigenesis.Genome instability: a conserved mechanism of ageing?Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier.Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk.A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden.One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin.Current Progresses of Single Cell DNA Sequencing in Breast Cancer Research.Mutation and catastrophe in the aging genome.Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.Universal Patterns of Selection in Cancer and Somatic Tissues.Using single-cell multiple omics approaches to resolve tumor heterogeneity.Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.Opportunities for organoids as new models of aging.Computational approaches for discovery of mutational signatures in cancer.Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin.Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis.Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.Aging and the rise of somatic cancer-associated mutations in normal tissues.Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues.
P2860
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P2860
Tissue-specific mutation accumulation in human adult stem cells during life.
description
2016 nĆ® lÅ«n-bĆ»n
@nan
2016幓ć®č«ę
@ja
2016幓č«ę
@yue
2016幓č«ę
@zh-hant
2016幓č«ę
@zh-hk
2016幓č«ę
@zh-mo
2016幓č«ę
@zh-tw
2016幓č®ŗę
@wuu
2016幓č®ŗę
@zh
2016幓č®ŗę
@zh-cn
name
Tissue-specific mutation accumulation in human adult stem cells during life.
@en
type
label
Tissue-specific mutation accumulation in human adult stem cells during life.
@en
prefLabel
Tissue-specific mutation accumulation in human adult stem cells during life.
@en
P2093
P2860
P50
P356
P1433
P1476
Tissue-specific mutation accumulation in human adult stem cells during life.
@en
P2093
Caroline L Wiegerinck
Edward E S Nieuwenhuis
Edwin Cuppen
Francis Blokzijl
Hans Clevers
Inigo Martincorena
Isaac J Nijman
Jan N M IJzermans
Jeroen de Jonge
Luc J W van der Laan
P2860
P2888
P304
P356
10.1038/NATURE19768
P407
P50
P577
2016-10-03T00:00:00Z