about
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingThe beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsSingle-cell dissection of transcriptional heterogeneity in human colon tumorsSingle Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheWnt activates the Tak1/Nemo-like kinase pathwayLong-term culture of genome-stable bipotent stem cells from adult human liverUnlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axisDifferentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumCrypt stem cells as the cells-of-origin of intestinal cancerTranscription factor achaete scute-like 2 controls intestinal stem cell fateBeta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinBNegative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumorsPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsCyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.WNT signaling and lymphocyte development.In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infectionTransformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis.Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastasesGenome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cellsDll1+ secretory progenitor cells revert to stem cells upon crypt damage.The intestinal stem cell.Wnt activation and alternative promoter repression of LEF1 in colon cancer.Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.Tissue-specific mutation accumulation in human adult stem cells during life.Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected.Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes
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P50
description
onderzoeker
@nl
name
Marc van de Wetering
@ast
Marc van de Wetering
@en
Marc van de Wetering
@es
Marc van de Wetering
@nl
Marc van de Wetering
@sl
type
label
Marc van de Wetering
@ast
Marc van de Wetering
@en
Marc van de Wetering
@es
Marc van de Wetering
@nl
Marc van de Wetering
@sl
prefLabel
Marc van de Wetering
@ast
Marc van de Wetering
@en
Marc van de Wetering
@es
Marc van de Wetering
@nl
Marc van de Wetering
@sl
P106
P21
P31
P569
2000-01-01T00:00:00Z