Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
about
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potentialComparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responsesCD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responsesEffects of CD70 and CD11a in immune thrombocytopenia patients.CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunityUnchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis.Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsTGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin's lymphoma.Distinct motifs in the intracellular domain of human CD30 differentially activate canonical and alternative transcription factor NF-κB signalingHIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhance T cell mediated anti-viral immunityCD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.Immunotherapy in allogeneic hematopoietic stem cell transplantation--not just a case for effector cells.T cell vaccinology: exploring the known unknowns.Human virus-specific CD8+ T cells: diversity specialists.CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.T Cell Vaccinology: Beyond the Reflection of Infectious ResponsesA cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory.The role of TNF superfamily members in T-cell function and diseases.Optimizing dendritic cell-based immunotherapy: tackling the complexity of different arms of the immune system.Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy.Therapeutic targeting of CD70 and CD27.Priming of CD8+ T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells.Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes.CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization.CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles.Properties of murine (CD8+)CD27- T cells.Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma.PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
P2860
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P2860
Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Stimulation by soluble CD70 pr ...... oxic T cell responses in vivo.
@en
type
label
Stimulation by soluble CD70 pr ...... oxic T cell responses in vivo.
@en
prefLabel
Stimulation by soluble CD70 pr ...... oxic T cell responses in vivo.
@en
P1476
Stimulation by soluble CD70 pr ...... toxic T cell responses in vivo
@en
P2093
Aymen Al-Shamkhani
P304
P356
10.4049/JIMMUNOL.172.10.6039
P407
P577
2004-05-01T00:00:00Z