The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
about
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexRole that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysisTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyAKT/PKB signaling: navigating downstreamMolecular basis of physiological heart growth: fundamental concepts and new playersLipid biology of breast cancerPhosphoinositides: Key modulators of energy metabolismMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistancePDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα InhibitionUbiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1Essential role of PDK1 in regulating endothelial cell migrationFeedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signalingRequirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survivalRegulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathwayA novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.Phosphatidylinositol 3-kinase: the oncoprotein.HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents.Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.PH motifs in PAR1&2 endow breast cancer growth.Computational Analysis of the Binding Specificities of PH Domains.The TSC1-TSC2 complex is required for proper activation of mTOR complex 2Reconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domainsAnalysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.New insights into the regulation and function of serine/threonine kinases in T lymphocytes.
P2860
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P2860
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The in vivo role of PtdIns(3,4 ...... n defined by knockin mutation.
@en
type
label
The in vivo role of PtdIns(3,4 ...... n defined by knockin mutation.
@en
prefLabel
The in vivo role of PtdIns(3,4 ...... n defined by knockin mutation.
@en
P2093
P2860
P356
P1433
P1476
The in vivo role of PtdIns(3,4 ...... n defined by knockin mutation.
@en
P2093
Barry J Collins
Edward J McManus
J Simon C Arthur
Laura J Armit
Peter R Ashby
Victoria Murray-Tait
P2860
P304
P356
10.1038/SJ.EMBOJ.7600218
P407
P577
2004-04-29T00:00:00Z