Killing of target cells by redirected granzyme B in the absence of perforin.
about
Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysmAugmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape EnhancersListeriolysin O as cytotoxic component of an immunotoxinGranzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.Delivery and therapeutic potential of human granzyme B.Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm.Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosisIntracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity.Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2).Defining the mechanism(s) of protection by cytolytic CD8 T cells against a cryptic epitope derived from a retroviral alternative reading frame.The functionalized human serine protease granzyme B/VEGF₁₂₁ targets tumor vasculature and ablates tumor growth.Function and Potentials of M. tuberculosis EpitopesCell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris.Design and characterization of a novel human Granzyme B inhibitor.Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathwayTargeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway.Anti-ROR1 scFv-EndoG as a Novel Anti-Cancer Therapeutic DrugGranzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.PSA-selective activation of cytotoxic human serine proteases within the tumor microenvironment as a therapeutic strategy to target prostate cancer.Human Granzyme B Based Targeted Cytolytic Fusion Proteins.
P2860
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P2860
Killing of target cells by redirected granzyme B in the absence of perforin.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Killing of target cells by redirected granzyme B in the absence of perforin.
@en
type
label
Killing of target cells by redirected granzyme B in the absence of perforin.
@en
prefLabel
Killing of target cells by redirected granzyme B in the absence of perforin.
@en
P2093
P2860
P1433
P1476
Killing of target cells by redirected granzyme B in the absence of perforin.
@en
P2093
Dieter E Jenne
Edward Fellows
Florian C Kurschus
Hauke Lilie
Klaus Dornmair
Martin Kleinschmidt
Rainer Rudolph
P2860
P356
10.1016/S0014-5793(04)00187-5
P407
P577
2004-03-01T00:00:00Z