Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
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Cell cycle-specific function of Ikaros in human leukemiaSerine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosRole of Ikaros in T-cell acute lymphoblastic leukemiaInactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiencyIkaros SUMOylation: switching out of repressionIkaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.Interferon regulatory factor 4 and 8 in B-cell development.A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylationIRF4 is a suppressor of c-Myc induced B cell leukemia.Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.AF10 plays a key role in the survival of uncommitted hematopoietic cells.Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.A novel, non-canonical splice variant of the Ikaros gene is aberrantly expressed in B-cell lymphoproliferative disorders.Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasisRegulator of myeloid differentiation and function: The secret life of Ikaros.The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer.Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell developmentClinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemiaThe role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation.Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.Protein kinase CK2 in development and differentiation.Ikaros, CK2 kinase, and the road to leukemia.Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1.Zinc finger structure-function in Ikaros Marvin A Payne.Ikaros and tumor suppression in acute lymphoblastic leukemiaThe diverse roles of IRF4 in late germinal center B-cell differentiation.Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.The BET bromodomain inhibitor CPI203 improves lenalidomide and dexamethasone activity in in vitro and in vivo models of multiple myeloma by blockade of Ikaros and MYC signaling.Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation.The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros.Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms.
P2860
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P2860
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
@en
type
label
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
@en
prefLabel
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
@en
P2093
P2860
P1476
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
@en
P2093
Katia Georgopoulos
Kazushige Maki
Pablo Gómez-del Arco
P2860
P304
P356
10.1128/MCB.24.7.2797-2807.2004
P407
P577
2004-04-01T00:00:00Z