Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency
about
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesCtIP is required to initiate replication-dependent interstrand crosslink repairDNA resection in eukaryotes: deciding how to fix the breakHigh resolution genomic analysis of 18q- using oligo-microarray comparative genomic hybridization (aCGH)Role of Deubiquitinating Enzymes in DNA RepairModeling the study of DNA damage responses in miceDouble-strand break repair on sex chromosomes: challenges during male meiotic prophaseThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesCOM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joiningCtIP Mutations Cause Seckel and Jawad SyndromesNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairProcessing of damaged DNA ends for double-strand break repair in mammalian cellsHuman CtIP mediates cell cycle control of DNA end resection and double strand break repairMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairTargeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethalitySystematic Discovery of In Vivo Phosphorylation NetworksCtp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationMRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.CtIP-mediated resection is essential for viability and can operate independently of BRCA1.End resection at double-strand breaks: mechanism and regulation.Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairRelease of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombinationTetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.Enhanced tumour cell nuclear targeting in a tumour progression model.Mutual exclusivity analysis identifies oncogenic network modules.BRCA1 tumor suppressor network: focusing on its tail.CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivoMitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem CellsA novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 geneA conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination.Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.CtIP promotes microhomology-mediated alternative end joining during class-switch recombinationMechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
P2860
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P2860
Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@ast
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@en
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
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type
label
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@ast
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@en
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@nl
prefLabel
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@ast
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@en
Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@nl
P2093
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P921
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Inactivation of CtIP leads to ...... nesis by haploid insufficiency
@en
P2093
Bingnan Gu
Eva Y-H P Lee
Phang-Lang Chen
Wen-Hwa Lee
Xiaoqin Lin
Yumay Chen
P2860
P304
P3181
P356
10.1128/MCB.25.9.3535-3542.2005
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P577
2005-05-01T00:00:00Z