Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. - Wikidata - wikimedia - TriplyDB

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

http://www.wikidata.org/entity/Q40596813

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Identifying microRNA/mRNA dysregulations in ovarian cancer Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I Primer extension-based method for the generation of a siRNA/miRNA expression vector.In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors Targeting protein prenylation for cancer therapy Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines A novel approach to tag and identify geranylgeranylated proteins.The same and not the same: heterogeneous functional activation of prostate tumor cells by TLR ligation IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation Survivin and escaping in therapy-induced cellular senescence.Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.Inhibition of geranylgeranyl transferase-I decreases cell viability of HTLV-1-transformed cells.GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.Survivin expression in tuberous sclerosis complex cells.Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells.Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish.Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure.TLR signaling by tumor and immune cells: a double-edged sword.The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.Survivin mediates renal proximal tubule recovery from AKI.Transcriptional regulation of the survivin gene.Oncogenes associated with drug resistance in ovarian cancer.Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells.Molecular diagnosis and molecular profiling to detect treatment-resistant ovarian cancer.Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation.Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.Inhibition of survivin expression after using oxaliplatin and vinflunine to induce cytogenetic damage in vitro in lymphocytes from colon cancer patients and healthy individuals.

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Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

http://www.wikidata.org/entity/Q40596813

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Phosphatidylinositol-3-OH kina ...... I inhibitor-induced apoptosis.

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Phosphatidylinositol-3-OH kina ...... I inhibitor-induced apoptosis.

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Phosphatidylinositol-3-OH kina ...... I inhibitor-induced apoptosis.

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Phosphatidylinositol-3-OH kina ...... I inhibitor-induced apoptosis.

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P2093

Andrew Hamilton

http://www.w3.org/2001/XMLSchema#string

Han C Dan

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Jin Q Cheng

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Kun Jiang

http://www.w3.org/2001/XMLSchema#string

Said M Sebti

http://www.w3.org/2001/XMLSchema#string

Santo V Nicosia

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P2860

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells.

Actin' up: RhoB in cancer and apoptosis.

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

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706-715

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10.1038/SJ.ONC.1207171

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3

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23

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Domenico Coppola

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2004-01-01T00:00:00Z

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8908534

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1000320094

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14737105

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