Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.
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Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patientsAntibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in miceSmall molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.A requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in cultureMolecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC)FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancerInternational Myeloma Working Group molecular classification of multiple myeloma: spotlight review.Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreadingFGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancerMosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms.A cell of origin gene signature indicates human bladder cancer has distinct cellular progenitors.Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3Evolving treatment strategies for myeloma.Ribosomal protein metallopanstimulin-1 impairs multiple myeloma CAG cells growth and inhibits fibroblast growth factor receptor 3.Targeting signalling pathways for the treatment of multiple myeloma.Urothelial tumorigenesis: a tale of divergent pathways.Fibroblast growth factor receptor 3 (FGFR3) associated with the CD20 antigen regulates the rituximab-induced proliferation inhibition in B-cell lymphoma cellsNovel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma.Genetic events in the pathogenesis of multiple myeloma.Clinical implications of chromosomal abnormalities in multiple myeloma.The role of microenvironment in tumor angiogenesis.Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.Advances in immunotherapy of multiple myeloma: from the discovery of tumor-associated antigens to clinical trials.Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic targetPreclinical studies of novel targeted therapies.Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors.Differential regulation of FGFR3 by PTPN1 and PTPN2.Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.Targeting mutant fibroblast growth factor receptors in cancer.Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy.The over-expression of FGFR4 could influence the features of gastric cancer cells and inhibit the efficacy of PD173074 and 5-fluorouracil towards gastric cancer.Tyrosine Kinase Inhibitors as Antiangiogenic Drugs in Multiple MyelomaFGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.Targeting fibroblast growth factor receptor 3 enhances radiosensitivity in human squamous cancer cells.MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
P2860
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P2860
Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Inhibition of fibroblast growt ...... apoptosis in t(4;14) myeloma.
@en
type
label
Inhibition of fibroblast growt ...... apoptosis in t(4;14) myeloma.
@en
prefLabel
Inhibition of fibroblast growt ...... apoptosis in t(4;14) myeloma.
@en
P2093
P1433
P1476
Inhibition of fibroblast growt ...... d apoptosis in t(4;14) myeloma
@en
P2093
Marta Chesi
Maurizio Affer
P Leif Bergsagel
Yildiz Farooqi
P304
P356
10.1182/BLOOD-2003-10-3650
P407
P577
2004-01-08T00:00:00Z